Evidence map›Paper›PMID 26982282›Full record

Trial reportBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2016

Premature Infants 750-1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner.

Amy B Hair, Erynn M Bergner, Martin L Lee, Alvaro G Moreira, Keli M Hawthorne, David J Rechtman, Steven A Abrams, Cynthia L Blanco

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  7. Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amy B Hair1 Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital , Houston, Texas.
Erynn M Bergner1 Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital , Houston, Texas.
Martin L Lee2 Prolacta Bioscience , Industry, California.
Alvaro G Moreira3 Department of Pediatrics, University of Texas Health Science Center , San Antonio, Texas.
Keli M Hawthorne4 Department of Pediatrics, Dell Medical School at the University of Texas at Austin , Austin, Texas.
David J Rechtman2 Prolacta Bioscience , Industry, California.
Steven A Abrams4 Department of Pediatrics, Dell Medical School at the University of Texas at Austin , Austin, Texas.
Cynthia L Blanco3 Department of Pediatrics, University of Texas Health Science Center , San Antonio, Texas.
The University of Texas at Austin · USThe University of Texas Health Science Center at San Antonio · US

Funding

NCRR NIH HHS RR00188
6 · The paper itself

Abstract

objectiveInfants may benefit from early nutritional intervention to decrease hospital stay. To evaluate the effects of adding a human milk (HM)-derived cream (Cream) product to a standard feeding regimen in preterm infants. MATERIALS AND

methodsIn a prospective multicenter randomized study, infants with birth weights 750-1,250 g were assigned to a Control or Cream group. The Control group received a standard feeding regimen consisting of mother's own milk or donor HM with donor HM-derived fortifier. The Cream group received the standard feeding regimen along with an additional HM-derived cream supplement when the HM they received was <20 kcal/oz. Primary outcomes of this secondary analysis included comorbidities, length of stay (LOS), and postmenstrual age (PMA) at discharge.

resultsWe enrolled 75 infants (Control n = 37, Cream n = 38) with gestational age 27.7 ± 1.8 weeks and birth weight 973 ± 145 g (mean ± SD). After adjusting for gestational age, birth weight, and presence of bronchopulmonary dysplasia (BPD), the Cream group had a decreased PMA at discharge (39.9 ± 4.8 versus 38.2 ± 2.7 weeks, p = 0.03) and LOS (86 ± 39 versus 74 ± 22 days, p = 0.05). For 21 infants with BPD, these values trended toward significance for PMA at discharge (44.2 ± 6.1 versus 41.3 ± 2.7 weeks, p = 0.08) and LOS (121 ± 49 versus 104 ± 23 days, p = 0.08).

conclusionsVery preterm infants who received an HM-derived cream supplement were discharged earlier. Infants with BPD may have benefited the most.

Indexed as

Dietary SupplementsFood, FortifiedInfant, Extremely Low Birth WeightInfant, Very Low Birth WeightLength of StayMilk, HumanBronchopulmonary DysplasiaChild DevelopmentFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureLinear ModelsMale

Identifiers

PMID26982282
PMCPMC4827298
OpenAlexW2299725830

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.