Evidence map›Paper›PMID 26981865›Full record

ArticlePloS one2016

Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias without Cardiovascular Adverse Effects.

Viswanathan Rajagopalan, Youhua Zhang, Kaie Ojamaa, Yue-Feng Chen, Alessandro Pingitore, Christine J Pol, Debra Saunders, Krithika Balasubramanian, Rheal A Towner, A Martin Gerdes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Viswanathan RajagopalanDepartment of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, Old Westbury, New York, United States of America.
Youhua ZhangDepartment of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, Old Westbury, New York, United States of America.
Kaie OjamaaFeinstein Institute for Medical Research, Manhasset, New York, United States of America.
Yue-Feng ChenDepartment of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, Old Westbury, New York, United States of America.
Alessandro PingitoreCNR Clinical Physiology Institute, Pisa, Italy.
Christine J PolDepartment of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, Old Westbury, New York, United States of America.
Debra SaundersOklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.
Krithika BalasubramanianOklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.
Rheal A TownerOklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.
A Martin GerdesDepartment of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, Old Westbury, New York, United States of America.
New York Institute of Technology · USOklahoma Medical Research Foundation · USFeinstein Institute for Medical Research · USIstituto di Fisiologia Clinica · IT

Funding

Low Thyroid function and myocardial infarctionR01HL103671 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI GERDES, ANTHONY MARTIN · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL103671NHLBI NIH HHS R01HL103671
6 · The paper itself

Abstract

backgroundA large body of evidence suggests that thyroid hormones (THs) are beneficial for the treatment of cardiovascular disorders. We have shown that 3 days of triiodo-L-thyronine (T3) treatment in myocardial infarction (MI) rats increased left ventricular (LV) contractility and decreased myocyte apoptosis. However, no clinically translatable protocol is established for T3 treatment of ischemic heart disease. We hypothesized that low-dose oral T3 will offer safe therapeutic benefits in MI. METHODS AND

resultsAdult female rats underwent left coronary artery ligation or sham surgeries. T3 (~6 μg/kg/day) was available in drinking water ad libitum immediately following MI and continuing for 2 month(s) (mo). Compared to vehicle-treated MI, the oral T3-treated MI group at 2 mo had markedly improved anesthetized Magnetic Resonance Imaging-based LV ejection fraction and volumes without significant negative changes in heart rate, serum TH levels or heart weight, indicating safe therapy. Remarkably, T3 decreased the incidence of inducible atrial tachyarrhythmias by 88% and improved remodeling. These were accompanied by restoration of gene expression involving several key pathways including thyroid, ion channels, fibrosis, sympathetic, mitochondria and autophagy.

conclusionsLow-dose oral T3 dramatically improved post-MI cardiac performance, decreased atrial arrhythmias and cardiac remodeling, and reversed many adverse changes in gene expression with no observable negative effects. This study also provides a safe and effective treatment/monitoring protocol that should readily translate to humans.

Indexed as

Administration, OralAnimalsArrhythmias, CardiacFemaleMagnetic Resonance ImagingMyocardial InfarctionRatsRats, Sprague-DawleyReal-Time Polymerase Chain ReactionTriiodothyronineTriiodothyronine

Identifiers

PMID26981865
PMCPMC4794221
OpenAlexW2297738084

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.