Evidence map›Paper›PMID 26981595›Full record

ArticleInvestigative and clinical urology2016

Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom.

Liam Toner, Nathan Papa, Sani H Aliyu, Harveer Dev, Nathan Lawrentschuk, Samih Al-Hayek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative and clinical urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Unraveling Biofilm-Forming Uropathogens: Isolation and Antimicrobial Resistance Patterns at Nepal Police Hospital, Kathmandu.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  4. Article
  5. Article
  6. Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2022
    Article
  7. Antimicrobial Susceptibility Testing for Enterococci.Journal of clinical microbiology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Revisiting Nitrofurantoin for Vancomycin Resistant Enterococci.Journal of clinical and diagnostic research : JCDR · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Liam TonerDepartment of Surgery, Urology Unit, University of Melbourne, Melbourne, Australia.
Nathan PapaDepartment of Surgery, Urology Unit, University of Melbourne, Melbourne, Australia.
Sani H AliyuDepartment of Microbiology, Addenbrookes' Hospital, Cambridge University, Cambridge, UK.
Harveer DevDepartment of Urology, Addenbrookes' Hospital, Cambridge University, Cambridge, UK.
Nathan LawrentschukDepartment of Surgery, Urology Unit, University of Melbourne, Melbourne, Australia.; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.; Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Samih Al-HayekDepartment of Urology, Addenbrookes' Hospital, Cambridge University, Cambridge, UK.
University of Cambridge · GBUniversity of Melbourne · AUOlivia Newton-John Cancer Wellness & Research Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEnterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat. The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin resistance in adults among urinary isolates of Enterococcus sp. and to detail the antibiotic susceptibility profile, which can be used to guide empirical treatment. MATERIALS AND

methodsFrom 2005 to 2014 we retrospectively reviewed 5,528 positive Enterococcus sp. urine cultures recorded in a computerized laboratory results database at a tertiary teaching hospital in Cambridge, United Kingdom.

resultsOf these cultures, 542 (9.8%) were vancomycin resistant. No longitudinal trend was observed in the proportion of vancomycin-resistant strains over the course of the study. We observed emerging resistance to nitrofurantoin with rates climbing from near zero to 40%. Ampicillin resistance fluctuated between 50% and 90%. Low resistance was observed for linezolid and quinupristin/dalfopristin. Female sex and inpatient status were identified as risk factors for vancomycin resistance.

conclusionsThe incidence of vancomycin resistance among urinary isolates was stable over the last decade. Although resistance to nitrofurantoin has increased, it still serves as an appropriate first choice in uncomplicated urinary tract infection caused by vancomycin-resistant Enterococcus sp.

Indexed as

Vancomycin ResistanceAgedDrug Resistance, BacterialEnglandFemaleGram-Positive Bacterial InfectionsHospitalizationHumansMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesRisk FactorsTertiary Care CentersUrinalysisUrinary Tract InfectionsAntibiotic prophylaxisEnterococcusMicrobial drug resistanceUrinary tract infectionVancomycin-resistant enterococci

Identifiers

PMID26981595
PMCPMC4791667
OpenAlexW2296338730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.