Genome-wide identification and analysis of mRNA expression in fibroblasts, ES cells, and iPS cells.

Hiroyuki Hirai, Nobuaki Kikyo

Open access · goldAbstract read

In one paragraph

Article in Genomics data, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hiroyuki HiraiStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA; Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Nobuaki KikyoStem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

University of Minnesota · US

Funding

Histone isomerization and pluripotencyR01GM098294 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2012 to 2015

$1.1M

Hypoxia and long noncoding RNAR21CA187232 · NCI · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2014 to 2015

$364k

NCI NIH HHS R21 CA187232NIGMS NIH HHS R01 GM098294

6 · The paper itself

Abstract

Genome-wide expression patterns of mRNA were compared between mouse embryonic fibroblasts (MEFs), embryonic stem cells (ESCs), and various types of induced pluripotent stem cells (iPSCs). iPSCs were established and maintained using modified Oct4 with or without exogenous leukemia inhibitory factor (LIF) and used to identify mRNAs that were potentially involved in the LIF-independence. The data have been deposited in the NCBI's Gene Expression Omnibus (GEO) database with the accession number GSE65563.

Indexed as

Induced pluripotent stem cellsLeukemia inhibitory factorOct4PluripotencyReprogramming

Identifiers

PMID26981399

DOI10.1016/j.gdata.2015.12.026

PMCPMC4778654

OpenAlexW2301219718

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.