ArticleStandards in genomic sciences2016
The complete genome sequence of Eubacterium limosum SA11, a metabolically versatile rumen acetogen.
Article in Standards in genomic sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Rumen-derived Prevotella and Megasphaera elsdenii mitigate methane production through functional modulation of rumen microbial metabolism.Journal of animal science and biotechnology · 2026Article
- Near-complete inhibition of rumen methanogenesis via microbial and enzymatic modulation using a low dose of Asparagopsis taxiformis combined with 3-nitrooxypropanol.Journal of animal science and biotechnology · 2026Article
- Yeast culture promotes butyrate produced fibrolytic bacteria as intracellular hydrogen sink in the rumen.Microbiome · 2026Article
- Article
- Cultivation and sequencing of microbiota members unveil the functional potential of yak gut microbiota.mSystems · 2025Article
- Refining and illuminating acetogenic Eubacterium strains for reclassification and metabolic engineering.Microbial cell factories · 2024Article
- Genome-wide CRISPRi screen identifies enhanced autolithotrophic phenotypes in acetogenic bacteriumProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dietary selection of metabolically distinct microorganisms drives hydrogen metabolism in ruminants.The ISME journal · 2022Article
- Expanding the genetic engineering toolbox for the metabolically flexible acetogen Eubacterium limosum.Journal of industrial microbiology & biotechnology · 2022Article
- Genome Sequence ofMicroorganisms · 2022Article
- Alternative pathway for dopamine production by acetogenic gut bacteria that O-Demethylate 3-Methoxytyramine, a metabolite of catechol O-Methyltransferase.Journal of applied microbiology · 2022Article
- Homo-Acetogens: Their Metabolism and Competitive Relationship with Hydrogenotrophic Methanogens.Microorganisms · 2022Review
- Comparative genomics and proteomics of Eubacterium maltosivorans: functional identification of trimethylamine methyltransferases and bacterial microcompartments in a human intestinal bacterium with a versatile lifestyle.Environmental microbiology · 2022Article
- Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria.Microbial genomics · 2022Article
- Genetic and metabolic engineering challenges of C1-gas fermenting acetogenic chassis organisms.FEMS microbiology reviews · 2021Review
- Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health.Microbiome · 2019Review
- Hydrogen cross-feeders of the human gastrointestinal tract.Gut microbes · 2019Review
- The Planktonic Core Microbiome and Core Functions in the Cattle Rumen by Next Generation Sequencing.Frontiers in microbiology · 2018Article
- Determination of the Genome and Primary Transcriptome of Syngas Fermenting Eubacterium limosum ATCC 8486.Scientific reports · 2017Article
- Microbial solvent formation revisited by comparative genome analysis.Biotechnology for biofuels · 2017Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetogens are a specialized group of anaerobic bacteria able to produce acetate from CO2 and H2 via the Wood-Ljungdahl pathway. In some gut environments acetogens can compete with methanogens for H2, and as a result rumen acetogens are of interest in the development of microbial approaches for methane mitigation. The acetogen Eubacterium limosum SA11 was isolated from the rumen of a New Zealand sheep and its genome has been sequenced to examine its potential application in methane mitigation strategies, particularly in situations where hydrogenotrophic methanogens are inhibited resulting in increased H2 levels in the rumen. The 4.15 Mb chromosome of SA11 has an average G + C content of 47 %, and encodes 3805 protein-coding genes. There is a single prophage inserted in the chromosome, and several other gene clusters appear to have been acquired by horizontal transfer. These include genes for cell wall glycopolymers, a type VII secretion system, cell surface proteins and chemotaxis. SA11 is able to use a variety of organic substrates in addition to H2/CO2, with acetate and butyrate as the principal fermentation end-products, and genes involved in these metabolic pathways have been identified. An unusual feature is the presence of 39 genes encoding trimethylamine methyltransferase family proteins, more than any other bacterial genome. Overall, SA11 is a metabolically versatile organism, but its ability to grow on such a wide range of substrates suggests it may not be a suitable candidate to take the place of hydrogen-utilizing methanogens in the rumen.
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