ReviewAdvances in nutrition (Bethesda, Md.)2016
Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.
Review in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- The Influence of Ketone Bodies on Circadian Processes Regarding Appetite, Sleep and Hormone Release: A Systematic Review of the Literature.Nutrients · 2022Pooled it
- An exposomics analysis of 125 biomarkers of exposure to food contaminants and biomarkers of oxidative stress: a randomized cross-over chrononutrition trial of healthy adults.Environment international · 2025Trial
- Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women.Nutrients · 2025Trial
- Glycemic and sleep effects of daytime compared with those of overnight infusions of home parenteral nutrition in adults with short bowel syndrome: A quasi-experimental pilot trial.The American journal of clinical nutrition · 2024Trial
- The metabolic effects of intermittent versus continuous feeding in critically ill patients.Scientific reports · 2023Trial
- Skipping Breakfast for 6 Days Delayed the Circadian Rhythm of the Body Temperature without Altering Clock Gene Expression in Human Leukocytes.Nutrients · 2020Trial
- Chronotype and social jetlag influence human circadian clock gene expression.Scientific reports · 2018Trial
- Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Trial
- Time-varying eating behaviors and long-term risk of incident hypertension in a Japanese cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Improving the Outcome of Brain-Injured Patients by Non-Continuous Feeding to Prevent Dysbiosis.Nutrients · 2026Review
- Dietary pattern and night work: metabolic syndrome in healthcare workers.Archives of endocrinology and metabolism · 2026Article
- Review
- Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology · 2026Article
- Chrononutrition, Body Composition, and Resting Metabolic Rate Among College Students: A Cross-Sectional Study.Nutrients · 2026Article
- Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study.Diabetes, obesity & metabolism · 2026Article
- Dietary rhythms and biological aging risk across multiple organs.NPJ science of food · 2026Article
- Chrono-Nutrition in Gestational Diabetes Mellitus: Implications of Meal Timing and Nutrient Distribution for Glycemic Control.Nutrients · 2026Review
- Contribution of habitual and meal-specific dietary inflammatory index and its associations with obesity and metabolic risk indicators in women.Nutrition journal · 2026Article
- Restoring circadian disrupted gut microbial metabolite rhythms with phytochemicals: a new avenue against metabolic disease.Frontiers in microbiology · 2026Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chrononutrition is an emerging discipline that builds on the intimate relation between endogenous circadian (24-h) rhythms and metabolism. Circadian regulation of metabolic function can be observed from the level of intracellular biochemistry to whole-organism physiology and even postprandial responses. Recent work has elucidated the metabolic roles of circadian clocks in key metabolic tissues, including liver, pancreas, white adipose, and skeletal muscle. For example, tissue-specific clock disruption in a single peripheral organ can cause obesity or disruption of whole-organism glucose homeostasis. This review explains mechanistic insights gained from transgenic animal studies and how these data are being translated into the study of human genetics and physiology. The principles of chrononutrition have already been demonstrated to improve human weight loss and are likely to benefit the health of individuals with metabolic disease, as well as of the general population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.