ReviewAdvances in nutrition (Bethesda, Md.)2016
Endogenous Synthesis of Amino Acids Limits Growth, Lactation, and Reproduction in Animals.
Review in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 83 citations in OpenAlex.
- Effects of Dietary Glycine Supplementation on Reproductive Outcomes and Early Piglet Growth in Local Black Gilts: Associations with Placental Traits and Maternal Gut Microbiota-Metabolome Profiles.Animals : an open access journal from MDPI · 2026Article
- Glycine as a Metabolic Regulator of Reproductive Function in Livestock: From Gametes to Early Embryos.Animals : an open access journal from MDPI · 2026Review
- Role of Nutritional Elements in Skin Homeostasis: A Review.Biomolecules · 2025Review
- Glutamate increases the lean percentage and intramuscular fat content and alters gut microbiota in Shaziling pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Low crude protein formulation with supplemental amino acids for its impacts on intestinal health and growth performance of growing-finishing pigs.Journal of animal science and biotechnology · 2024Article
- Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries.European journal of nutrition · 2024Article
- The nonessential amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia.Blood advances · 2024Article
- Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway.The ISME journal · 2024Article
- Protein quality of a small mammal prey and its body organs for felids.Journal of animal science · 2024Article
- Dietary glycine supplementation enhances creatine availability in tissues of pigs with intrauterine growth restriction.Journal of animal science · 2024Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- The optimal amino acid pattern for humans and its implications for nutrition of cancer patients.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024Article
- Nonessential amino acids in tropical ruminant feed: Investigating grass and legume forages of Indonesia.Journal of advanced veterinary and animal research · 2023Article
- Synthesis of glycine from 4-hydroxyproline in tissues of neonatal pigs with intrauterine growth restriction.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.EMBO reports · 2023Article
- Variation among arthropod taxa in the amino acid content of exoskeleton and digestible tissue.Ecology and evolution · 2023Article
- Peculiarities in the Amino Acid Composition of Sow Colostrum and Milk, and Their Potential Relevance to Piglet Development.Veterinary sciences · 2023Article
- Dietary glycine supplementation enhances the growth performance of hybrid striped bass (Morone saxatilis ♀× Morone chrysops ♂) fed soybean meal-based diets.Journal of animal science · 2023Article
- Effects of Different Prenatal Nutrition Strategies on the Liver Metabolome of Bulls and Its Correlation with Body and Liver Weight.Metabolites · 2022Article
- Effects of Dietary Multienzyme Complex Supplementation on Growth Performance, Digestive Capacity, Histomorphology, Blood Metabolites and Hepatic Glycometabolism in Snakehead (Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amino acids (AAs) are building blocks of protein. Eight AAs (Ala, Asn, Asp, Glu, Gln, Gly, Pro, and Ser) are formed by all animals, whereas de novo synthesis of Arg occurs in a species-specific manner in most mammals (e.g., humans, pigs, and rats). Synthesizable AAs were traditionally classified as nutritionally nonessential for animals, because they were thought to be formed in sufficient amounts. However, this assumption is not supported by evidence showing that 1) rats grow slowly when their diets do not contain Arg, Glu, or Gln despite adequate provision of all other proteinogenous AAs; 2) pigs cannot achieve maximum growth, lactation, or reproduction performance when fed corn- and soybean meal-based diets meeting National Research Council-recommended requirements of protein and AAs without supplemental Arg, Glu, Gln, Gly, or Pro; 3) chickens exhibit increases in lean tissue gain and feed efficiency when their diets are supplemented with Glu, Gln, Gly, and Pro; 4) lactating cows cannot obtain maximum milk protein production without a postruminal supply of Gln or Pro; 5) fish cannot achieve maximum growth when diets do not contain Gln or Pro; and 6) men fail to sustain spermatogenesis when fed an Arg-deficient diet. Quantitative analysis of nitrogen metabolism showed that AA synthesis in animals is constrained by both precursor availability and enzyme activity. Taken together, these findings support the conclusion that the endogenous synthesis of AAs limits growth, lactation, and reproduction in animals. This new knowledge can guide the optimization of human nutrition for improving health and well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.