Evidence map›Paper›PMID 26980727›Full record

ReviewBlood2016

The 2016 revision of the World Health Organization classification of lymphoid neoplasms.

Steven H Swerdlow, Elias Campo, Stefano A Pileri, Nancy Lee Harris, Harald Stein, Reiner Siebert, Ranjana Advani, Michele Ghielmini, Gilles A Salles, Andrew D Zelenetz and 1 more

6 registry-linked trialsAbstract readReview
In one paragraph

Review in Blood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 3,683 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3,683citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03391466 phase3completednot on this mapstarted 2018, after this paper: background citation

A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma (ZUMA-7)

TypeinterventionalSponsorKite, A Gilead CompanyRan2018 to 2024Enrolled359ConditionsRelapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)ArmsAxicabtagene Ciloleucel, Platinum-containing Salvage Chemotherapy, Cyclophosphamide, Fludarabine
NCT03823365 phase1unknown statusnot on this mapstarted 2018, after this paper: background citation

Immune Reconstitution With Blinatumomab Expanded T-cells (BET) After First-line Treatment With Fludarabine-Cyclophosphamide-Rituximab or Bendamustine-Rituximab in CD20+ Indolent Non-Hodgkin Lymphomas/Chronic Lymphocytic Leukemia: a Phase I Study

TypeinterventionalSponsorA.O. Ospedale Papa Giovanni XXIIIRan2018 to 2022Enrolled19ConditionsIndolent Non-Hodgkin Lymphomas/Chronic Lymphocytic LeukemiaArmsBlinatumomab Expanded T-cells (BET)
NCT04181489 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

A Phase II, Prospective, Multi-center Study of Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2019 to 2023Enrolled55ConditionsEBV-Positive DLBCL, NosArmsSintilimab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine
NCT04587388 unknown statusnot on this mapstarted 2019, after this paper: background citation

Towards Personalized Medicine for Refractory/Relapsed Follicular Lymphoma Patients: the Cantera/Lupiae Registry

Typeobservational_patient_registrySponsorEuropean Hematology Association - Lymphoma GroupRan2019 to 2026Enrolled500ConditionsFollicular Lymphoma, Relapsed/Refractory Follicular Lymphoma
NCT06024694 active not recruitingnot on this mapstarted 2022, after this paper: background citation

Retrospective Multicenter International Study on Prognostic Factors, Management And Outcome Of Primary Mediastinal Large B-Cell Lymphoma (PMLBCL) Patients With Central Nervous System (CNS) Involvement

TypeobservationalSponsorIRCCS San RaffaeleRan2022 to 2027Enrolled45ConditionsPrimary Mediastinal Large B-cell Lymphoma (PMBCL)
NCT07502118 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

An Open-Label, Multicenter Phase 2-3 Clinical Study of Anti-CD19 Chimeric Antigen Receptor T Cells (Talikabtagene Autoleucel) in Patients With Relapsed/Refractory B-Cell Malignancies (NexCAR19)

TypeinterventionalSponsorHealth Institutes of TurkeyRan2025 to 2030Enrolled40ConditionsRelapsed/Refractory B-cell Acute Lymphoblastic Leukemia (B-ALL), Relapsed/Refractory Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), High-grade B-cell Lymphoma (HGBCL)ArmsTalikabtagene Autoleucel
3 · Its place in the literature

Who cites it

3,683 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. International Myeloma Working Group Recommendations for the Diagnosis and Management of Solitary Plasmacytomas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Guideline
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3,623 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Steven H SwerdlowDivision of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;ORCID 0000-0002-3832-3329
Elias CampoDepartment of Pathology, Hospital Clinic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain;
Stefano A PileriHaematopathology Unit, European Institute of Oncology, Milan, and Department of Experimental, Diagnostic and Specialty Medicine, Bologna University Medical School, Bologna, Italy;
Nancy Lee HarrisDepartment of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA;
Harald SteinPathodiagnostik, Berlin, Germany;
Reiner SiebertInstitute of Human Genetics, Christian Albrechts University Kiel, Kiel, Germany;
Ranjana AdvaniDivision of Oncology, Department of Medicine, Stanford University, Stanford, CA;
Michele GhielminiDepartment of Medical Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;
Gilles A SallesDepartment of Hematology, Hospices Civils de Lyon, and Université Claude Bernard Lyon-1, Lyon, France;ORCID 0000-0002-9541-8666
Andrew D ZelenetzDepartment of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY; and.
Elaine S JaffeHematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD.ORCID 0000-0003-4632-0301

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Lymphoma Disease Discovery and DefintionZIASC000550 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$16.9M
Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

Indexed as

Genes, NeoplasmHumansLeukemia, LymphoidLymphatic DiseasesLymphocytesLymphomaOncogene Proteins, FusionParaproteinemiasWorld Health OrganizationOncogene Proteins, Fusion

Identifiers

PMID26980727
PMCPMC4874220

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.