Evidence map›Paper›PMID 26980620›Full record

ArticleInternational orthopaedics2016

A method of treatment for nonunion after fractures using mesenchymal stromal cells loaded on collagen microspheres and incorporated into platelet-rich plasma clots.

Olga Wittig, Egidio Romano, Cesar González, Dylana Diaz-Solano, Maria Elena Marquez, Pedro Tovar, Rodolfo Aoun, Jose E Cardier

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04545307 phase2 / phase3completednot on this mapstarted 2019, after this paper: background citation

Transplantation of Allogeneic Mesenchymal Stromal Cells in Patients With Immature Apex Teeth With Pulp Necrosis and Chronic Apical Periodontitis

TypeinterventionalSponsorUniversidad Central de VenezuelaRan2019 to 2020Enrolled5ConditionsPulp Necroses, Apical PeriodontitisArmsAllogenic transplant of BM-MSC in a root canal from patients with immature apexes and pulpar necrosis and apical periodontitis
NCT05975892 phase1 / phase2unknown statusnot on this mapstarted 2018, after this paper: background citation

Transplantation of Bone Marrow Mesenchymal Stromal Cells for Bone Regeneration in Periodontal Disease

TypeinterventionalSponsorInstituto Venezolano de Investigaciones CientificasRan2018 to 2024Enrolled30ConditionsChronic Periodontal Disease, Aggressive PeriodontitisArmsTransplantation of allogeneic MSCs in periodontal disease
NCT06103396 phase1 / phase2unknown statusnot on this mapstarted 2018, after this paper: background citation

Treatment of Nonunion After Fractures (Pseudoartrosis) Using Mesenchymal Stromal Cells (MSCs)

TypeinterventionalSponsorInstituto Venezolano de Investigaciones CientificasRan2018 to 2024Enrolled30ConditionsPseudoarthrosis of Bone, Pseudarthrosis, Non Union Fracture, Nonunion Bone FractureArmsTransplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Cellular therapies for bone repair: current insights.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024
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  12. The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olga WittigUnidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 21827, Caracas, 1020-A, Venezuela.
Egidio RomanoUnidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 21827, Caracas, 1020-A, Venezuela. egidio_romano@yahoo.es.
Cesar GonzálezServicio de Traumatología, Hospital Universitario de Caracas, Caracas, 1080, Venezuela.
Dylana Diaz-SolanoUnidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 21827, Caracas, 1020-A, Venezuela.
Maria Elena MarquezUnidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 21827, Caracas, 1020-A, Venezuela.
Pedro TovarServicio de Traumatología, Hospital Universitario de Caracas, Caracas, 1080, Venezuela.
Rodolfo AounServicio de Traumatología, Hospital Universitario de Caracas, Caracas, 1080, Venezuela.
Jose E CardierUnidad de Terapia Celular - Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 21827, Caracas, 1020-A, Venezuela. jcardier@ivic.gob.ve.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is evidence showing that mesenchymal stromal cells (MSC) may constitute a potential therapeutic strategy to induce bone regeneration. In this work, we investigate the capacity of autologous bone marrow (BM) MSC loaded on collagen microspheres (CM) and included into autologous platelet-rich plasma (PRP) clots (MSC/CM/PRP) to induce bone formation in patients with nonunion lesions.

methodsMSC were isolated from BM cells of patients with nonunion lesions. Phenotypical (marker expression) and functional studies (osteogenic differentiation) were performed. MSC were seeded on CM and included into autologous PRP clot (MSC/CM/PRP). The capacity of MSC/CM/PRP to induce bone formation was evaluated in three patients diagnosed with nonunion.

resultsMSC loaded on CM/PRP clots maintain their biological functions, in vitro. After three months, post-MSC transplantation, all patients showed evidence of osteogenesis at the site of nonunion. After one year, all patients showed a complete healing of the nonunion.

conclusionsOur results support the use of autologous MSC transplanted as MSC/CM/PRP for the treatment of nonunion fractures. Future studies incorporating a larger number of patients may confirm the results obtained in this work.

Indexed as

AdultAged, 80 and overBone RegenerationCollagenFemaleFractures, UnunitedHumansMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMicrospheresOsteogenesisPlatelet-Rich PlasmaWound HealingCollagenBone regenerationCollagenMesenchymal stromal cellsNonunionPRP

Identifiers

PMID26980620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.