Evidence map›Paper›PMID 26980522›Full record

ReviewProgress in biophysics and molecular biology2016

Biologic relativity: Who is the observer and what is observed?

John S Torday, William B Miller

Open access · greenAbstract readReview
In one paragraph

Review in Progress in biophysics and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John S TordayEvolutionary Medicine, UCLA, 1124 West Carson Street, Torrance, CA 90502-2006, USA. Electronic address: jtorday@labiomed.org.
William B MillerParadise Valley AZ, USA.
Paradise Valley Community College · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
HORMONAL REGULATION OF LUNG DEVELOPMENT;PTHrP BIOLOGYR01HL055268 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TORDAY, JOHN STEVEN · 1997 to 2009
$3.3M
NCRR NIH HHS M01 RR000425NHLBI NIH HHS R01 HL055268
6 · The paper itself

Abstract

When quantum physics and biological phenomena are analogously explored, it emerges that biologic causation must also be understood independently of its overt appearance. This is similar to the manner in which Bohm characterized the explicate versus the implicate order as overlapping frames of ambiguity. Placed in this context, the variables affecting epigenetic inheritance can be properly assessed as a key mechanistic principle of evolution that significantly alters our understanding of homeostasis, pleiotropy, and heterochrony, and the purposes of sexual reproduction. Each of these become differing manifestations of a new biological relativity in which biologic space-time becomes its own frame. In such relativistic cellular contexts, it is proper to question exactly who has observer status, and who and what are being observed. Consideration within this frame reduces biology to cellular information sharing through cell-cell communication to resolve ambiguities at every scope and scale. In consequence, it becomes implicit that eukaryotic evolution derives from the unicellular state, remaining consistently adherent to it in a continuous evolutionary arc based upon elemental, non-stochastic physiologic first principles. Furthermore, the entire cell including its cytoskeletal apparatus and membranes that participate in the resolution of biological uncertainties must be considered as having equivalent primacy with genomes in evolutionary terms.

Indexed as

Evolution, MolecularAnimalsGenomicsHumansPhenotypeBiologic relativity theoryCell–cell communicationEvolutionImplicate orderPhysiologic first principlesQuantum physicsThought experimentUnicell

Identifiers

PMID26980522
PMCPMC4854779
OpenAlexW2296733605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.