ArticleBMC complementary and alternative medicine2016
In vivo and in vitro evaluation of the effects of Urtica dioica and swimming activity on diabetic factors and pancreatic beta cells.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- PVA/chitosan-based hydrogels integrated with tilapia skin-derived collagen and Urtica dioica offers a promising approach for effective burn wound healing via transcriptional modulation of bFgf, Mmp2, Jak/Stat3, and α-Sma signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Prophylactic Coloprotective Effect ofMedicina (Kaunas, Lithuania) · 2023Article
- Protective Effect ofLife (Basel, Switzerland) · 2023Article
- Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential.Current issues in molecular biology · 2023Review
- Evidence-Based Anti-Diabetic Properties of Plant from the Occitan Valleys of the Piedmont Alps.Pharmaceutics · 2022Review
- Stinging Nettle (Molecules (Basel, Switzerland) · 2022Review
- Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review.International journal of environmental research and public health · 2022Review
- Review
- A review of the effects ofIranian journal of basic medical sciences · 2022Review
- Bioprospecting the Metabolome of PlantEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Middle East Medicinal Plants in the Treatment of Diabetes: A Review.Molecules (Basel, Switzerland) · 2021Review
- Herbal Medicines Targeting the ImprovedEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Therapeutic Perspectives of Molecules fromMolecules (Basel, Switzerland) · 2019Review
- Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus.Integrative medicine research · 2018Article
- Article
- Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D).Scientific reports · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrtica dioica (UD) has been identified as a traditional herbal medicine. This study aimed to investigate the effect of UD extract and swimming activity on diabetic parameters through in vivo and in vitro experiments.
methodsAdult WKY male rats were randomly distributed in nine groups: intact control, diabetic control, diabetic + 625 mg/kg, 1.25 g/kg UD, diabetic + 100 mg/kg Metformin, diabetic + swimming, diabetic + swimming 625 mg/kg, 1.25 g/kg UD, and diabetic +100 mg/kg Metformin + swimming. The hearts of the animals were punctured, and blood samples were collected for biochemical analysis. The entire pancreas was exposed for histologic examination. The effect of UD on insulin secretion by RIN-5F cells in 6.25 or 12.5 mM glucose dose was examined. Glucose uptake by cultured L6 myotubes was determined.
resultsThe serum glucose concentration decreased, the insulin resistance and insulin sensitivity significantly increased in treated groups. These changes were more pronounced in the group that received UD extract and swimming training. Regeneration and less beta cell damage of Langerhans islets were observed in the treated groups. UD treatment increased insulin secretion in the RIN-5F cells and glucose uptake in the L6 myotubes cells.
conclusionsSwimming exercises accompanied by consuming UD aqueous extracts effectively improved diabetic parameters, repaired pancreatic tissues in streptozotocin-induced diabetics in vivo, and increased glucose uptake or insulin in UD-treated cells in vitro.
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