Evidence map›Paper›PMID 26980363›Full record

Trial reportThe Journal of frailty & aging2016

Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms.

V M Dotson, F C Hsu, T Y Langaee, C W McDonough, A C King, R A Cohen, A B Newman, S B Kritchevsky, V Myers, T M Manini and 2 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of frailty & aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Impact of cardiovascular risk factors on the relationships of physical activity with mood and cognitive function in a diverse sample.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2023
    Article
  10. Interaction Effect between Physical Activity and theInternational journal of environmental research and public health · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Lifestyle,Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

V M DotsonVonetta Dotson, Ph.D., Department of Clinical and Health, Psychology, University of Florida, P.O. Box 100165, Gainesville, FL 32610-0165, USA. Phone: +1 (352) 273-6041. Fax: +1 (352) 273-6156. Email: vonetta@phhp.ufl.edu.
F C Hsu
T Y Langaee
C W McDonough
A C King
R A Cohen
A B Newman
S B Kritchevsky
V Myers
T M Manini
M Pahor
LIFE STUDY GROUP
University of Florida Health · US

Funding

UF FIELD CENTERU01AG022376 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PAHOR, MARCO · 2003 to 2015
$83.3M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Research Training in Disability &Disabling DisordersK24AG021507 · NIA · YALE UNIVERSITY · PI GILL, THOMAS MICHAEL · 2003 to 2012
$1.6M
Intramural NIH HHSNCATS NIH HHS KL2 TR001429NCATS NIH HHS UL1 TR001427NIA NIH HHS 1 P30 AG21332NIA NIH HHS K24 AG021507NIA NIH HHS K24AG021507NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG028740-01NIA NIH HHS U01 AG022376NIA NIH HHS U01AG22376
6 · The paper itself

Abstract

backgroundConverging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are not always consistent. These mixed results might reflect heterogeneity in response to physical activity, with some subgroups of individuals responding positively, but not others.

objectives1) To examine the impact of genetic variation and sex on changes in depressive symptoms in older adults after a physical activity (PA) intervention, and 2) to determine if PA differentially improves particular symptom dimensions of depression.

designRandomized controlled trial.

settingFour field centers (Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University).

participants396 community-dwelling adults aged 70-89 years who participated in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P).

intervention12-month PA intervention compared to an education control. MEASUREMENTS: Polymorphisms in the serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF), and apolipoprotein E (APOE) genes; 12-month change in the Center for Epidemiologic Studies Depression Scale total score, as well as scores on the depressed affect, somatic symptoms, and lack of positive affect subscales.

resultsMen randomized to the PA arm showed the greatest decreases in somatic symptoms, with a preferential benefit in male carriers of the BDNF Met allele. Symptoms of lack of positive affect decreased more in men compared to women, particularly in those possessing the 5-HTT L allele, but the effect did not differ by intervention arm. APOE status did not affect change in depressive symptoms.

conclusionsResults of this study suggest that the impact of PA on depressive symptoms varies by genotype and sex, and that PA may mitigate somatic symptoms of depression more than other symptoms. The results suggest that a targeted approach to recommending PA therapy for treatment of depression is viable.

Indexed as

DepressionLife StyleMotor ActivityAgedAged, 80 and overApolipoproteins EBrain-Derived Neurotrophic FactorExercise TherapyFemaleHumansIndependent LivingMalePolymorphism, GeneticPsychiatric Status Rating ScalesSerotonin Plasma Membrane Transport ProteinsSex FactorsApolipoproteins EBDNF protein, humanBrain-Derived Neurotrophic FactorSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID26980363
PMCPMC4905714
OpenAlexW2298924175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.