SynthesisSchizophrenia bulletin2016
Diagnostic Stability of ICD/DSM First Episode Psychosis Diagnoses: Meta-analysis.
Synthesis in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- The severity of dissociation and dissociative phenomena in non-affective psychosis: a systematic review and meta-analyses.BMC psychiatry · 2026Pooled it
- Systematic Review and Meta-Analysis: Risk Factors of Violence During First-Episode Psychosis.Trauma, violence & abuse · 2026Pooled it
- Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section.Molecular psychiatry · 2025Pooled it
- The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies.Translational psychiatry · 2024Pooled it
- The predictive validity and outcome of ICD-10 and DSM-5 short-lived psychotic disorders: a review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2022Pooled it
- Clinical outcomes in brief psychotic episodes: a systematic review and meta-analysis.Epidemiology and psychiatric sciences · 2021Pooled it
- Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2020Pooled it
- Peripheral Biomarkers in Schizophrenia: A Meta-Analysis of Microarray Gene Expression Datasets.The international journal of neuropsychopharmacology · 2019Pooled it
- Guidelines for the Pharmacotherapy of Schizophrenia in Adults.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Long noncoding RNAs as novel serum biomarkers for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Pooled it
- Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Symptom predominance, treatment delay, and four-year remission outcomes in first-episode schizophrenia: A single-center cohort from Turkiye.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- Prefrontal Circuitry Abnormalities and Cognitive Impairment in Adolescents with Early- Onset Psychosis.Research square · 2026Article
- Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia.International journal of methods in psychiatric research · 2026Article
- Women with first-episode psychosis: diagnostic stability and clinical trajectories.Archives of women's mental health · 2026Observational
- Predictors of conversion to psychosis and mortality in first-episode substance-induced psychosis: a nationwide register-based study in South Korea.Schizophrenia (Heidelberg, Germany) · 2026Article
- Baseline household income is associated with severity and course of severe mental illness.Psychological medicine · 2026Article
- Long-term diagnostic and social outcomes after first psychiatric hospitalization.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Identifying Transdiagnostic Predictors of Depression across Psychoses: Informing Stratified Antidepressant Treatments.Psychotherapy and psychosomatics · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundValidity of current International Classification of Disease/Diagnostic and Statistical Manual of Mental Disorders (ICD/DSM) first episode psychosis diagnoses is essential in clinical practice, research, training and public health.
methodWe provide a meta-analytical estimate of prospective diagnostic stability and instability in ICD-10 or DSM-IV first episode diagnoses of functional psychoses. Independent extraction by multiple observers. Random effect meta-analysis conducted with the "metaprop," "metaninf," "metafunnel," "metabias," and "metareg" packages of STATA13.1. Moderators were tested with meta-regression analyses. Heterogeneity was assessed with the I
findings42 studies and 45 samples were included, for a total of 14 484 first episode patients and an average follow-up of 4.5 years. Prospective diagnostic stability ranked: schizophrenia 0.90 (95% CI 0.85-0.95), affective spectrum psychoses 0.84 (95% CI 0.79-0.89), schizoaffective disorder 0.72 (95% CI 0.61-0.73), substance-induced psychotic disorder 0.66 (95% CI 0.51-0.81), delusional disorder 0.59 (95% CI 0.47-0.71), acute and transient psychotic disorder/brief psychotic disorder 0.56 (95% CI 0.62-0.60), psychosis not otherwise specified 0.36 (95% CI 0.27-0.45, schizophreniform disorder 0.29 (95% CI 0.22-0.38). Diagnostic stability within schizophrenia spectrum psychoses was 0.93 (95% CI 0.89-0.97); changes to affective spectrum psychoses were 0.05 (95% CI 0.01-0.08). About 0.10 (95% CI 0.05-0.15) of affective spectrum psychoses changed to schizophrenia spectrum psychosis. Across the other psychotic diagnoses there was high diagnostic instability, mostly to schizophrenia.
interpretationThere is meta-analytical evidence for high prospective diagnostic stability in schizophrenia spectrum and affective spectrum psychoses, with no significant ICD/DSM differences. These results may inform the development of new treatment guidelines for early psychosis and impact drug licensing from regulatory agencies.
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