ArticleScientific reports2016
In vivo acoustic and photoacoustic focusing of circulating cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Acoustic Streaming-Based 3D Cell Focusing and Plasma Separation.Micromachines · 2026Article
- Hierarchical Nanostructures as Acoustically Manipulatable Multifunctional Agents in Dynamic Fluid Flow.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- High speed innovations in photoacoustic microscopy.Npj imaging · 2024Review
- Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions.Micromachines · 2023Review
- Non-Invasive Dynamic Reperfusion of MicrovesselsFrontiers in bioengineering and biotechnology · 2022Article
- Ultrasonic Particle Manipulation in Glass Capillaries: A Concise Review.Micromachines · 2021Review
- Dynamic blood flow phantom for in vivo liquid biopsy standardization.Scientific reports · 2021Article
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- In Vivo Optofluidic Switch for Controlling Blood Microflow.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Acoustic Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020Review
- Review
- Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.Royal Society open science · 2019Article
- Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives.International journal of nanomedicine · 2019Review
- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.Light, science & applications · 2019Article
- Acoustic tweezers for the life sciences.Nature methods · 2018Review
- Noninvasive label-free detection of circulating white and red blood clots in deep vessels with a focused photoacoustic probe.Biomedical optics express · 2018Article
- Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer.Chemical science · 2018Article
- Biomolecular Ultrasound and Sonogenetics.Annual review of chemical and biomolecular engineering · 2018Review
- Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.Trends in cancer · 2018Review
- In vivo noninvasive microscopy of human leucocytes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In vivo flow cytometry using vessels as natural tubes with native cell flows has revolutionized the study of rare circulating tumor cells in a complex blood background. However, the presence of many blood cells in the detection volume makes it difficult to count each cell in this volume. We introduce method for manipulation of circulating cells in vivo with the use of gradient acoustic forces induced by ultrasound and photoacoustic waves. In a murine model, we demonstrated cell trapping, redirecting and focusing in blood and lymph flow into a tight stream, noninvasive wall-free transportation of blood, and the potential for photoacoustic detection of sickle cells without labeling and of leukocytes targeted by functionalized nanoparticles. Integration of cell focusing with intravital imaging methods may provide a versatile biological tool for single-cell analysis in circulation, with a focus on in vivo needleless blood tests, and preclinical studies of human diseases in animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.