ArticleGenome biology and evolution2016
Whole-Genome Identification, Phylogeny, and Evolution of the Cytochrome P450 Family 2 (CYP2) Subfamilies in Birds.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Changes in the Expression of Some Genes With Metabolic, VLDL and Antioxidative Effects After the Addition of Essential Oil Mixture to Drinking Water in the Liver of Domestic Geese (Anser anser Domesticus).Veterinary medicine and science · 2025Article
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- A Critical Review on the Dosing and Safety of Antifungals Used in Exotic Avian and Reptile Species.Journal of fungi (Basel, Switzerland) · 2023Review
- Putative Antimicrobial Peptides of the Posterior Salivary Glands from the CephalopodAntibiotics (Basel, Switzerland) · 2020Article
- Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.BMC evolutionary biology · 2020Article
- Beyond drugs: the evolution of genes involved in human response to medications.Proceedings. Biological sciences · 2019Article
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- Conservation Genomics in the Sagebrush Sea: Population Divergence, Demographic History, and Local Adaptation in Sage-Grouse (Centrocercus spp.).Genome biology and evolution · 2019Article
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- Application of different pharmacokinetic models to describe and predict pharmacokinetics of voriconazole in magellanic penguins following oral administration.Journal of veterinary pharmacology and therapeutics · 2019Article
- Complex gene expansion of theEcology and evolution · 2018Article
- Evolution of CYP2J19, a gene involved in colour vision and red coloration in birds: positive selection in the face of conservation and pleiotropy.BMC evolutionary biology · 2018Article
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- Detoxification and elimination of nicotine by nectar-feeding birds.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cytochrome P450 (CYP) superfamily defends organisms from endogenous and noxious environmental compounds, and thus is crucial for survival. However, beyond mammals the molecular evolution of CYP2 subfamilies is poorly understood. Here, we characterized the CYP2 family across 48 avian whole genomes representing all major extant bird clades. Overall, 12 CYP2 subfamilies were identified, including the first description of the CYP2F, CYP2G, and several CYP2AF genes in avian genomes. Some of the CYP2 genes previously described as being lineage-specific, such as CYP2K and CYP2W, are ubiquitous to all avian groups. Furthermore, we identified a large number of CYP2J copies, which have been associated previously with water reabsorption. We detected positive selection in the avian CYP2C, CYP2D, CYP2H, CYP2J, CYP2K, and CYP2AC subfamilies. Moreover, we identified new substrate recognition sites (SRS0, SRS2_SRS3, and SRS3.1) and heme binding areas that influence CYP2 structure and function of functional importance as under significant positive selection. Some of the positively selected sites in avian CYP2D are located within the same SRS1 region that was previously linked with the metabolism of plant toxins. Additionally, we find that selective constraint variations in some avian CYP2 subfamilies are consistently associated with different feeding habits (CYP2H and CYP2J), habitats (CYP2D, CYP2H, CYP2J, and CYP2K), and migratory behaviors (CYP2D, CYP2H, and CYP2J). Overall, our findings indicate that there has been active enzyme site selection on CYP2 subfamilies and differential selection associated with different life history traits among birds.
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