Evidence map›Paper›PMID 26979740›Full record

ArticleJournal of physiology and biochemistry2016

Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas.

Jumpei Soeda, Angelina Mouralidarane, Paul Cordero, Jiawei Li, Vi Nguyen, Rebeca Carter, Sabrina R Kapur, Joaquim Pombo, Lucilla Poston, Paul D Taylor and 2 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jumpei SoedaInstitute for Liver and Digestive Health, University College London, London, UK.
Angelina MouralidaraneInstitute for Liver and Digestive Health, University College London, London, UK.
Paul CorderoInstitute for Liver and Digestive Health, University College London, London, UK.
Jiawei LiInstitute for Liver and Digestive Health, University College London, London, UK.
Vi NguyenInstitute for Liver and Digestive Health, University College London, London, UK.
Rebeca CarterInstitute for Liver and Digestive Health, University College London, London, UK.
Sabrina R KapurInstitute for Liver and Digestive Health, University College London, London, UK.
Joaquim PomboDivision of Women's Health, King's College London, London, UK.
Lucilla PostonDivision of Women's Health, King's College London, London, UK.
Paul D TaylorDivision of Women's Health, King's College London, London, UK.
Manlio VinciguerraInstitute for Liver and Digestive Health, University College London, London, UK. m.vinciguerra@ucl.ac.uk.
Jude A ObenInstitute for Liver and Digestive Health, University College London, London, UK. j.oben@ucl.ac.uk.
University College London · GBKing's College London · GBSt Thomas' Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H008845/1Wellcome Trust
6 · The paper itself

Abstract

The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mice model of adult and perinatal diet-induced obesity. Twenty female C57BL/6J mice were assigned to control (Con) or obesogenic (Ob) diets prior to and during pregnancy and lactation. Their offspring were weaned onto Con or Ob diets up to 6 months post-partum. Then, after sacrifice, plasma biochemical analyses, gene expression, and protein concentrations were measured in pancreata. Offspring of Ob-fed mice had significantly increased body weight (p < 0.001) and plasma leptin (p < 0.001) and decreased insulin (p < 0.01) levels. Maternal obesogenic diet decreased the total and phosphorylated Eif2α and increased spliced X-box binding protein 1 (XBP1). Pancreatic gene expression of downstream regulators of UPR (EDEM, homocysteine-responsive endoplasmic reticulum-resident (HERP), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP)) and autophagy-related proteins (LC3BI/LC3BII) were differently disrupted by obesogenic feeding in both mothers and offspring (from p < 0.1 to p < 0.001). Maternal obesity and Ob feeding in their offspring alter UPR in NAFPD, with involvement of proapoptotic and autophagy-related markers. Upstream and downstream regulators of PERK, IRE1α, and ATF6 pathways were affected differently following the obesogenic insults.

Indexed as

Endoplasmic Reticulum StressMaternal Nutritional Physiological PhenomenaUnfolded Protein ResponseAnimalsAutophagyBiomarkersDietary SucroseDiet, High-FatFemaleGene Expression Regulation, DevelopmentalInsulinLactationLeptinMice, Inbred C57BLObesityPancreasBiomarkersDietary SucroseInsulinLeptinAutophagyER stressFatty pancreasObesityPerinatal programmingUPR

Identifiers

PMID26979740
PMCPMC4873529
OpenAlexW2297298708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.