Evidence map›Paper›PMID 26979516›Full record

ArticleCurrent genetics2016

The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae.

Kamlesh Kumar Yadav, Ram Rajasekharan

Abstract read
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In one paragraph

Article in Current genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of yeast mCurrent genetics · 2018
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kamlesh Kumar YadavLipidomic Centre, Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, 570020, India.
Ram RajasekharanLipidomic Centre, Department of Lipid Science, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, 570020, India. ram@cftri.com.
Academy of Scientific and Innovative Research · INCentral Food Technological Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PHM8 is a very important enzyme in nonpolar lipid metabolism because of its role in triacylglycerol (TAG) biosynthesis under phosphate stress conditions. It is positively regulated by the PHO4 transcription factor under low phosphate conditions; however, its regulation has not been explored under normal physiological conditions. General control nonderepressible (GCN4), a basic leucine-zipper transcription factor activates the transcription of amino acids, purine biosynthesis genes and many stress response genes under various stress conditions. In this study, we demonstrate that the level of TAG is regulated by the transcription factor GCN4. GCN4 directly binds to its consensus recognition sequence (TGACTC) in the PHM8 promoter and controls its expression. The analysis of cells expressing the P

Indexed as

Gene Expression Regulation, FungalBasic-Leucine Zipper Transcription FactorsGene Expression ProfilingGene Knockout TechniquesLipid MetabolismMetabolomicsMutationPromoter Regions, GeneticProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTriglyceridesBasic-Leucine Zipper Transcription FactorsGCN4 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTriglyceridesLipid dropletsLysophosphatidic acid phosphataseRepressorTranscriptional regulationTriacylglycerol

Identifiers

PMID26979516
OpenAlexW2296860334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.