Evidence map›Paper›PMID 26979256›Full record

ArticleBMJ (Clinical research ed.)2016

Refugee migration and risk of schizophrenia and other non-affective psychoses: cohort study of 1.3 million people in Sweden.

Anna-Clara Hollander, Henrik Dal, Glyn Lewis, Cecilia Magnusson, James B Kirkbride, Christina Dalman

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04867447 (Prevalence of Traumatic Events and Post-traumatic Stress Disorder in Immigrant and Non-immigrant Patients With Psychotic Disorder), which is not on this map. Cited by 100 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 5 pooled it
42.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04867447 completednot on this mapstarted 2019, after this paper: background citation

Prevalence of Traumatic Events and Post-traumatic Stress Disorder in Immigrant and Non-immigrant Patients With Psychotic Disorder

TypeobservationalSponsorParc de Salut MarRan2019 to 2023Enrolled199ConditionsPsychotic Disorders, Psychological Trauma, Stress, Psychological, Cross-Cultural ComparisonArmsPsychological trauma evaluation
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 5 syntheses or guidelines pooled it, 240 citations in OpenAlex.

  1. Pooled it
  2. Migration and schizophrenia: meta-analysis and explanatory framework.European archives of psychiatry and clinical neuroscience · 2020
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anna-Clara HollanderDepartment of Public Health Sciences, Karolinska Institutet, 171 77 Stockholm, Sweden anna-clara.hollander@ki.se.
Henrik DalCentre for Epidemiology and Community Medicine, Stockholm County Council, SE-171 77 Stockholm, Sweden.
Glyn LewisDivision of Psychiatry, University College London, London W1T 7NF, UK.
Cecilia MagnussonDepartment of Public Health Sciences, Karolinska Institutet, 171 77 Stockholm, Sweden Centre for Epidemiology and Community Medicine, Stockholm County Council, SE-171 77 Stockholm, Sweden.
James B KirkbrideDivision of Psychiatry, University College London, London W1T 7NF, UK.
Christina DalmanDepartment of Public Health Sciences, Karolinska Institutet, 171 77 Stockholm, Sweden Centre for Epidemiology and Community Medicine, Stockholm County Council, SE-171 77 Stockholm, Sweden.
Karolinska Institutet · SEUniversity College London · GBStockholm County Council · SE

Funding

Wellcome Trust 101272Wellcome Trust 101272/Z/13/Z
6 · The paper itself

Abstract

objectiveTo determine whether refugees are at elevated risk of schizophrenia and other non-affective psychotic disorders, relative to non-refugee migrants from similar regions of origin and the Swedish-born population.

designCohort study of people living in Sweden, born after 1 January 1984 and followed from their 14th birthday or arrival in Sweden, if later, until diagnosis of a non-affective psychotic disorder, emigration, death, or 31 December 2011.

settingLinked Swedish national register data.

participants1,347,790 people, including people born in Sweden to two Swedish-born parents (1,191,004; 88.4%), refugees (24,123; 1.8%), and non-refugee migrants (132,663; 9.8%) from four major refugee generating regions: the Middle East and north Africa, sub-Saharan Africa, Asia, and Eastern Europe and Russia.

main outcome measuresCox regression analysis was used to estimate adjusted hazard ratios for non-affective psychotic disorders by refugee status and region of origin, controlling for age at risk, sex, disposable income, and population density.

results3704 cases of non-affective psychotic disorder were identified during 8.9 million person years of follow-up. The crude incidence rate was 38.5 (95% confidence interval 37.2 to 39.9) per 100,000 person years in the Swedish-born population, 80.4 (72.7 to 88.9) per 100,000 person years in non-refugee migrants, and 126.4 (103.1 to 154.8) per 100,000 person years in refugees. Refugees were at increased risk of psychosis compared with both the Swedish-born population (adjusted hazard ratio 2.9, 95% confidence interval 2.3 to 3.6) and non-refugee migrants (1.7, 1.3 to 2.1) after adjustment for confounders. The increased rate in refugees compared with non-refugee migrants was more pronounced in men (likelihood ratio test for interaction χ(2) (df=2) z=13.5; P=0.001) and was present for refugees from all regions except sub-Saharan Africa. Both refugees and non-refugee migrants from sub-Saharan Africa had similarly high rates relative to the Swedish-born population.

conclusionsRefugees face an increased risk of schizophrenia and other non-affective psychotic disorders compared with non-refugee migrants from similar regions of origin and the native-born Swedish population. Clinicians and health service planners in refugee receiving countries should be aware of a raised risk of psychosis in addition to other mental and physical health inequalities experienced by refugees.

Indexed as

AdolescentAdultAfrica South of the SaharaAgedAge DistributionEurope, EasternFemaleHumansMaleMiddle AgedProportional Hazards ModelsPsychotic DisordersRefugeesRussiaSchizophreniaSex Distribution

Identifiers

PMID26979256
PMCPMC4793153
OpenAlexW2298599425

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.