ReviewGut microbes2016
Investigating a holobiont: Microbiota perturbations and transkingdom networks.
Review in Gut microbes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis.Environmental microbiology · 2026Article
- Holobiont-holobiont interactions across host-ectoparasite systems.Parasites & vectors · 2025Review
- The effects of stress on gut virome: Implications on infectious disease and systemic disorders.MicrobiologyOpen · 2024Review
- Host response to cholestyramine can be mediated by the gut microbiota.Microbiome research reports · 2024Article
- Article
- Subgingival host-microbiome metatranscriptomic changes following scaling and root planing in grade II/III periodontitis.Journal of clinical periodontology · 2023Article
- Harnessing the Power of Model Organisms To Unravel Microbial Functions in the Coral Holobiont.Microbiology and molecular biology reviews : MMBR · 2022Review
- Age-Related Cancer-Associated Microbiota Potentially Promotes Oral Squamous Cell Cancer Tumorigenesis by Distinct Mechanisms.Frontiers in microbiology · 2022Article
- Prediction and validation of host-pathogen interactions by a versatile inference approach usingComputational and structural biotechnology journal · 2022Article
- Comparison of Gut Microbiota Diversity Between Captive and Wild Tokay Gecko (Frontiers in microbiology · 2022Article
- Circadian dynamics of the teleost skin immune-microbiome interface.Microbiome · 2021Article
- Article
- The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Sepsis: deriving biological meaning and clinical applications from high-dimensional data.Intensive care medicine experimental · 2021Review
- Review
- Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes.Nature communications · 2021Article
- Microbiomes other than the gut: inflammaging and age-related diseases.Seminars in immunopathology · 2020Review
- Microbiota Modulates the Immunomodulatory Effects of Filifolinone on Atlantic Salmon.Microorganisms · 2020Article
- Interspecies Communication in Holobionts by Non-Coding RNA Exchange.International journal of molecular sciences · 2020Review
- Gut Microbiota and Cancer of the Host: Colliding Interests.Advances in experimental medicine and biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The scientific community has recently come to appreciate that, rather than existing as independent organisms, multicellular hosts and their microbiota comprise a complex evolving superorganism or metaorganism, termed a holobiont. This point of view leads to a re-evaluation of our understanding of different physiological processes and diseases. In this paper we focus on experimental and computational approaches which, when combined in one study, allowed us to dissect mechanisms (traditionally named host-microbiota interactions) regulating holobiont physiology. Specifically, we discuss several approaches for microbiota perturbation, such as use of antibiotics and germ-free animals, including advantages and potential caveats of their usage. We briefly review computational approaches to characterize the microbiota and, more importantly, methods to infer specific components of microbiota (such as microbes or their genes) affecting host functions. One such approach called transkingdom network analysis has been recently developed and applied in our study. (1) Finally, we also discuss common methods used to validate the computational predictions of host-microbiota interactions using in vitro and in vivo experimental systems.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.