Evidence map›Paper›PMID 26979052›Full record

ReviewNeuroscience2017

The neural basis of reversal learning: An updated perspective.

A Izquierdo, J L Brigman, A K Radke, P H Rudebeck, A Holmes

Abstract readReview
In one paragraph

Review in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 357 papers.

0numbers the graph read from it
0cells of the map it votes in
357citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

357 citing papers in PubMed.

  1. Trial
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  9. Cognitive functions of the GPe.Trends in neurosciences · 2026
    Review
  10. Article
  11. Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Article
  19. Effects of Histamine HNeuropsychopharmacology reports · 2026
    Article
  20. Article

297 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A IzquierdoDepartment of Psychology, The Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: aizquie@psych.ucla.edu.
J L BrigmanDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
A K RadkeLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
P H RudebeckDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10014, USA.
A HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.

Funding

Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7M
Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
NIAAA NIH HHS P50 AA022534
6 · The paper itself

Abstract

Reversal learning paradigms are among the most widely used tests of cognitive flexibility and have been used as assays, across species, for altered cognitive processes in a host of neuropsychiatric conditions. Based on recent studies in humans, non-human primates, and rodents, the notion that reversal learning tasks primarily measure response inhibition, has been revised. In this review, we describe how cognitive flexibility is measured by reversal learning and discuss new definitions of the construct validity of the task that are serving as a heuristic to guide future research in this field. We also provide an update on the available evidence implicating certain cortical and subcortical brain regions in the mediation of reversal learning, and an overview of the principal neurotransmitter systems involved.

Indexed as

AnimalsBrainHumansNeuronsReversal Learningamygdaladopaminefrontal cortexglutamateserotoninstriatum

Identifiers

PMID26979052
PMCPMC5018909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.