Evidence map›Paper›PMID 26978793›Full record

ArticleeLife2016

A simple generative model of the mouse mesoscale connectome.

Sid Henriksen, Rich Pang, Mark Wronkiewicz

Abstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025
    Article
  5. A generative model of the connectome with dynamic axon growth.bioRxiv : the preprint server for biology · 2024
    Article
  6. A generative model of the connectome with dynamic axon growth.Network neuroscience (Cambridge, Mass.) · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. A Student's Guide to Neural Circuit Tracing.Frontiers in neuroscience · 2019
    Review
  11. Article
  12. Specificity and robustness of long-distance connections in weighted, interareal connectomes.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  13. Multi-scale brain networks.NeuroImage · 2017
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sid HenriksenLaboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, United States.ORCID http://orcid.org/0000-0002-4335-4218
Rich PangGraduate Program in Neuroscience, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-2644-6110
Mark WronkiewiczGraduate Program in Neuroscience, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-6521-3256

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent technological advances now allow for the collection of vast data sets detailing the intricate neural connectivity patterns of various organisms. Oh et al. (2014) recently published the most complete description of the mouse mesoscale connectome acquired to date. Here we give an in-depth characterization of this connectome and propose a generative network model which utilizes two elemental organizational principles: proximal attachment ‒ outgoing connections are more likely to attach to nearby nodes than to distant ones, and source growth ‒ nodes with many outgoing connections are likely to form new outgoing connections. We show that this model captures essential principles governing network organization at the mesoscale level in the mouse brain and is consistent with biologically plausible developmental processes.

Indexed as

ConnectomeNeural Networks, ComputerAnimalsMicecomputational biologygraph theorymesoscalemousemouse connectomenetwork analysisneuroscienceproximal attachmentsource growthsystems biology

Identifiers

PMID26978793
PMCPMC4807721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.