ArticleInternational journal of molecular sciences2016
Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio).
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Water Hardness Can Reduce the Accumulation and Oxidative Stress of Zinc in Goldfish,Antioxidants (Basel, Switzerland) · 2022Article
- Trace elements, peripheral blood film, and gene expression status in adolescents living near an industrial area in the Colombian Caribbean Coastline.Journal of exposure science & environmental epidemiology · 2022Article
- Genome-Wide Identification and Analysis of the Metallothionein Genes inInternational journal of molecular sciences · 2021Article
- Antarctic Fish as a Global Pollution Sensor: Metals Biomonitoring in a Twelve-Year Period.Frontiers in molecular biosciences · 2021Article
- Hydroethanolic extract fromToxicology reports · 2020Article
- The roles of potassium channels in contractile response to urotensin-II in mercury chloride induced endothelial dysfunction in rat aorta.Iranian journal of veterinary research · 2018Article
- Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2017Article
- Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride.International journal of molecular sciences · 2017Article
- Metallothionein Gene Family in the Sea Urchin Paracentrotus lividus: Gene Structure, Differential Expression and Phylogenetic Analysis.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mercury (Hg) is a highly hazardous pollutant widely used in industrial, pharmaceutical and agricultural fields. Mercury is found in the environment in several forms, elemental, inorganic (iHg) and organic, all of which are toxic. Considering that the liver is the organ primarily involved in the regulation of metabolic pathways, homeostasis and detoxification we investigated the morphological and ultrastructural effects in Danio rerio liver after 96 h exposure to two low HgCl₂ concentrations (7.7 and 38.5 μg/L). We showed that a short-term exposure to very low concentrations of iHg severely affects liver morphology and ultrastructure. The main effects recorded in this work were: cytoplasm vacuolization, decrease in both lipid droplets and glycogen granules, increase in number of mitochondria, increase of rough endoplasmic reticulum and pyknotic nuclei. Pathological alterations observed were dose dependent. Trough immunohistochemistry, in situ hybridization and real-time PCR analysis, the induction of metallothionein (MT) under stressor conditions was also evaluated. Some of observed alterations could be considered as a general response of tissue to heavy metals, whereas others (such as increased number of mitochondria and increase of RER) may be considered as an adaptive response to mercury.
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