Evidence map›Paper›PMID 26978351›Full record

ReviewInternational journal of molecular sciences2016

Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease.

Ahmed S Bayoumi, Amer Sayed, Zuzana Broskova, Jian-Peng Teoh, James Wilson, Huabo Su, Yao-Liang Tang, Il-Man Kim

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 226 citations in OpenAlex.

  1. Article
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  4. Review
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  12. Review
  13. Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2023
    Review
  14. Article
  15. Article
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  17. Review
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  19. Review
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ahmed S BayoumiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. abayoumi@gru.edu.
Amer SayedDepartment of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. asayed@gru.edu.
Zuzana BroskovaVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. zbroskova@gru.edu.
Jian-Peng TeohVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. jteoh@gru.edu.
James WilsonDepartment of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. jamwilson@gru.edu.
Huabo SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. hsu@gru.edu.
Yao-Liang TangVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. yaotang@gru.edu.
Il-Man KimVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. ilkim@gru.edu.
Augusta University · US

Funding

Neddylation and cardiac protein quality controlR01HL124248 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2014 to 2024
$4.1M
Beta-arrestin signaling and microRNA biogenesis in cardioprotectionR01HL124251 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, IL-MAN · 2014 to 2018
$1.9M
American Heart Association-American Stroke Association 14SDG18970040NHLBI NIH HHS R01 HL124248NHLBI NIH HHS R01 HL124251
6 · The paper itself

Abstract

Protein-coding genes account for only a small part of the human genome; in fact, the vast majority of transcripts are comprised of non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs) and small ncRNAs, microRNAs (miRs). Accumulating evidence indicates that ncRNAs could play critical roles in regulating many cellular processes which are often implicated in health and disease. For example, ncRNAs are aberrantly expressed in cancers, heart diseases, and many other diseases. LncRNAs and miRs are therefore novel and promising targets to be developed into biomarkers for diagnosis and prognosis as well as treatment options. The interaction between lncRNAs and miRs as well as its pathophysiological significance have recently been reported. Mechanistically, it is believed that lncRNAs exert "sponge-like" effects on various miRs, which subsequently inhibits miR-mediated functions. This crosstalk between two types of ncRNAs frequently contributes to the pathogenesis of the disease. In this review, we provide a summary of the recent studies highlighting the interaction between these ncRNAs and the effects of this interaction on disease pathogenesis and regulation.

Indexed as

DiseaseDisease ProgressionGene Expression RegulationHumansMicroRNAsRNA, Long NoncodingMicroRNAsRNA, Long Noncodingcancerchromatinepigenetic regulationgene regulationheart diseasenon-coding RNAs

Identifiers

PMID26978351
PMCPMC4813217
OpenAlexW2295032943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.