Evidence map›Paper›PMID 26978339›Full record

ArticleMolecules (Basel, Switzerland)2016

Synthesis, Characterization and in Vitro Evaluation of Manganese Ferrite (MnFe2O4) Nanoparticles for Their Biocompatibility with Murine Breast Cancer Cells (4T1).

Samikannu Kanagesan, Sidek Bin Ab Aziz, Mansor Hashim, Ismayadi Ismail, Subramani Tamilselvan, Noorjahan Banu Binti Mohammed Alitheen, Mallappa Kumara Swamy, Bandaru Purna Chandra Rao

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. NiO/MnFeACS omega · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samikannu KanagesanMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia. kanagu1980@gmail.com.
Sidek Bin Ab AzizMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia. sidekaziz@gmail.com.
Mansor HashimMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia. mansorhashim@gmail.com.
Ismayadi IsmailMaterials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia. kayzen@gmail.com.
Subramani TamilselvanDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. drstamilselvan@gmail.com.
Noorjahan Banu Binti Mohammed AlitheenDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. noorjahan@upm.edu.my.
Mallappa Kumara SwamyDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. swamy.bio@gmail.com.
Bandaru Purna Chandra RaoDepartment of Applied Science and Humanities, Sasi Intitute of Technology and Engineering, Tadepalligudem, West Godavari District 534101, Andhra Pradesh, India. nanopurna@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manganese ferrite (MnFe2O4) magnetic nanoparticles were successfully prepared by a sol-gel self-combustion technique using iron nitrate and manganese nitrate, followed by calcination at 150 °C for 24 h. Calcined sample was systematically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrational sample magnetometry (VSM) in order to identify the crystalline phase, functional group, morphology, particle size, shape and magnetic behavior. It was observed that the resultant spinal ferrites obtained at low temperature exhibit single phase, nanoparticle size and good magnetic behavior. The study results have revealed the existence of a potent dose dependent cytotoxic effect of MnFe2O4 nanoparticles against 4T1 cell lines at varying concentrations with IC50 values of 210, 198 and 171 μg/mL after 24 h, 48 h and 72 h of incubation, respectively. Cells exposed to higher concentrations of nanoparticles showed a progressive increase of apoptotic and necrotic activity. Below 125 μg/mL concentration the nanoparticles were biocompatible with 4T1 cells.

Indexed as

AnimalsApoptosisBiocompatible MaterialsCell Line, TumorDose-Response Relationship, DrugFemaleFerric CompoundsMagnetite NanoparticlesMammary Neoplasms, ExperimentalManganese CompoundsMaterials TestingMiceMicroscopy, Electron, TransmissionSpectroscopy, Fourier Transform InfraredX-Ray DiffractionBiocompatible MaterialsFerric CompoundsMagnetite NanoparticlesManganese Compoundsmanganese ferritebreast cancercytotoxicitymagnetizationmanganese ferritenanoparticles

Identifiers

PMID26978339
PMCPMC6273739

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.