Evidence map›Paper›PMID 26978185›Full record

ArticleJournal of psychiatric research2016

Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.

Jaya L Padmanabhan, Pranav Nanda, Neeraj Tandon, Suraj S Mothi, Nicolas Bolo, Steven McCarroll, Brett A Clementz, Elliot S Gershon, Godfrey D Pearlson, John A Sweeney and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Jaya L PadmanabhanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Behavioral Neurology and Neuropsychiatry, McLean Hospital, Belmont, MA, USA.
Pranav NandaCollege of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA.
Neeraj TandonDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Baylor College of Medicine, Texas Medical Center, Houston, TX, USA.
Suraj S MothiDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nicolas BoloDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Steven McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Brett A ClementzDepartment of Psychology, BioImaging Research Center, University of Georgia, Athens, GA, USA; Department of Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USA; Department of Human Genetics, University of Chicago, IL, USA.
Godfrey D PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA; Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
John A SweeneyDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Carol A TammingaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: mkeshava@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USThe University of Texas Southwestern Medical Center · USBaylor College of Medicine · USBroad Institute · USColumbia University Irving Medical Center · USHarvard University · USInstitute for Community Living · USUniversity of Chicago · USUniversity of Georgia · US

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077852 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI THAKER, GUNVANT K · 2007 to 2010
$3.5M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychoticsK08MH083888 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BISHOP, JEFFREY R · 2009 to 2013
$899k
Enhancing Cognition in SchizophreniaK23MH072767 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HILL, SCOT KRISTIAN · 2006 to 2010
$794k
NIMH NIH HHS K08 MH083888NIMH NIH HHS K23 MH072767NIMH NIH HHS MH072767NIMH NIH HHS MH077851NIMH NIH HHS MH077852NIMH NIH HHS MH077862NIMH NIH HHS MH077945NIMH NIH HHS MH078113NIMH NIH HHS MH083888NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077852NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113
6 · The paper itself

Abstract

backgroundAn elevated prevalence of Type 2 diabetes (T2D) has been observed in people with psychotic disorders and their relatives compared to the general population. It is not known whether this population also has increased genetic risk for T2D.

methodsSubjects included probands with schizophrenia, schizoaffective disorder, or psychotic bipolar I disorder, their first-degree relatives without psychotic disorders, and healthy controls, who participated in the Bipolar Schizophrenia Network for Intermediate Phenotypes study. We constructed sets of polygenic risk scores for T2D (PGRST2D) and schizophrenia (PGRSSCHIZ) using publicly available data from genome-wide association studies. We then explored the correlation of PGRST2D with psychiatric proband or relative status, and with self-reported diabetes. Caucasians and African-Americans were analyzed separately. We also evaluated correlations between PGRSSCHIZ and diabetes mellitus among Caucasian probands and their relatives.

resultsIn Caucasians, PGRST2D was correlated with self-reported diabetes mellitus within probands, but was not correlated with proband or relative status in the whole sample. In African-Americans, a PGRST2D based on selected risk alleles for T2D in this population did not correlate with proband or relative status. PGRSSCHIZ was not correlated with self-reported diabetes within Caucasian probands.

conclusionDifferences in polygenic risk for T2D do not explain the increased prevalence of diabetes mellitus observed in psychosis probands and their relatives.

Indexed as

Genetic Predisposition to DiseaseMultifactorial InheritanceAdultAntipsychotic AgentsBlack or African AmericanDiabetes Mellitus, Type 2FamilyFemaleGenome-Wide Association StudyHumansLogistic ModelsMaleMiddle AgedPrevalencePsychotic DisordersRiskAntipsychotic AgentsBipolarDiabetesGeneticPolygenicPsychosisSchizophrenia

Identifiers

PMID26978185
PMCPMC4826806
OpenAlexW2276532150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.