Evidence map›Paper›PMID 26978062›Full record

ArticlePloS one2016

Bortezomib Inpatient Prescribing Practices in Free-Standing Children's Hospitals in the United States.

Amanda M DiNofia, Elizabeth Salazar, Alix E Seif, Yimei Li, Yuan-Shung Vera Huang, Rochelle Bagatell, Brian T Fisher, Richard Aplenc

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amanda M DiNofiaDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Elizabeth SalazarDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Alix E SeifDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Yimei LiDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Yuan-Shung Vera HuangCenter for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Rochelle BagatellDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Brian T FisherDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Richard AplencDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
CANCER CLINICAL EPIDEMIOLOGY TRAINING GRANTT32CA009679 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Richard Aplenc, Karen Glanz · 1992 to 2026
$11.1M
Toxicity Monitoring on Phase III Trials with Administrative DataR01CA165277 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI APLENC, RICHARD · 2012 to 2015
$1.8M
Pediatric Pharmacoepidemiology Training ProgramT32HD064567 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ADAMSON, PETER C., HENNESSY, SEAN · 2010 to 2014
$1.4M
NCI NIH HHS 5T32CA009679-24NCI NIH HHS P30 CA016520NCI NIH HHS R01 CA165277NCI NIH HHS R01CA165277NCI NIH HHS T32 CA009679NICHD NIH HHS 5T32HD064567-05NICHD NIH HHS T32 HD064567
6 · The paper itself

Abstract

This study is a pharmacoepidemiologic description of pediatric bortezomib use. Exposure was identified through billing codes in patients admitted to US children's hospitals that participated with the Pediatric Health Information System between 2004 and 2013. Associated information on underlying diseases, demographics, institutional use, mortality, and physician type was collected. Exposure to bortezomib was identified in 314 patients. Hematologist/Oncologists prescribed half of the bortezomib used. Use increased during the study period. Inpatient volume was positively correlated with bortezomib utilization. Bortezomib use in pediatrics is increasing for a variety of diseases. Variation in use exists across institutions. Further studies are needed to characterize bortezomib's efficacy in pediatric diseases.

Indexed as

Drug PrescriptionsHospitals, PediatricPractice Patterns, Physicians'AdolescentBortezomibChildHumansInpatientsUnited StatesBortezomib

Identifiers

PMID26978062
PMCPMC4792468
OpenAlexW2298594206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.