ArticlePloS one2016
Altered Spontaneous Activity in Patients with Persistent Somatoform Pain Disorder Revealed by Regional Homogeneity.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation.Frontiers in aging neuroscience · 2021Pooled it
- Clinical efficacy of the mulligan maneuver for cervicogenic headache: a randomized controlled trial.Scientific reports · 2023Trial
- Brain networks activated when aggravating baseline chronic pain of an individual with new daily persistent headache: a case study.BMC neurology · 2025Article
- Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression.BMC psychiatry · 2025Article
- Multi-network dynamical structure of the human brain in the setting of chronic pain: a coordinate-based meta-analysis.Brain communications · 2025Article
- Hypoconnectivity of the Amygdala in Patients with Low-Back-Related Leg Pain Linked to Individual Mechanical Pain Sensitivity: A Resting-State Functional MRI Study.Journal of pain research · 2023Article
- Recommendations for the Development of Socioeconomically-Situated and Clinically-Relevant Neuroimaging Models of Pain.Frontiers in neurology · 2021Article
- Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain.NeuroImage · 2020Article
- Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder.Neuropsychiatric disease and treatment · 2020Article
- Altered gray matter volumes in post-stroke depressive patients after subcortical stroke.NeuroImage. Clinical · 2020Article
- Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study.Clinical oral investigations · 2019Article
- Altered Brain Functional Hubs and Connectivity Underlie Persistent Somatoform Pain Disorder.Frontiers in neuroscience · 2019Article
- Bidirectional alterations in ALFF across slow-5 and slow-4 frequencies in the brains of postherpetic neuralgia patients.Journal of pain research · 2019Article
- Frequency-specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function.Human brain mapping · 2018Article
- Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change.American journal of translational research · 2018Article
- Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment.Frontiers in neuroscience · 2018Article
- Assessment of synchronous neural activities revealed by regional homogeneity in individuals with acute eye pain: a resting-state functional magnetic resonance imaging study.Journal of pain research · 2018Article
- Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis.European child & adolescent psychiatry · 2017Article
- Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent somatoform pain disorder (PSPD) is a mental disorder un-associated with any somatic injury and can cause severe somatosensory and emotional impairments in patients. However, so far, the neuro-pathophysiological mechanism of the functional impairments in PSPD is still unclear. The present study assesses the difference in regional spontaneous activity between PSPD and healthy controls (HC) during a resting state, in order to elucidate the neural mechanisms underlying PSPD. Resting-state functional Magnetic Resonance Imaging data were obtained from 13 PSPD patients and 23 age- and gender-matched HC subjects in this study. Kendall's coefficient of concordance was used to measure regional homogeneity (ReHo), and a two-sample t-test was subsequently performed to investigate the ReHo difference between PSPD and HC. Additionally, the correlations between the mean ReHo of each survived area and the clinical assessments were further analyzed. Compared with the HC group, patients with PSPD exhibited decreased ReHo in the bilateral primary somatosensory cortex, posterior cerebellum, and occipital lobe, while increased ReHo in the prefrontal cortex (PFC) and default mode network (including the medial PFC, right inferior parietal lobe (IPL), and left supramarginal gyrus). In addition, significant positive correlations were found between the mean ReHo of both right IPL and left supramarginal gyrus and participants' Self-Rating Anxiety Scale (SAS) scores, and between the mean ReHo of the left middle frontal gyrus and Visual Analogue Scale (VAS) scores. Our results suggest that abnormal spontaneous brain activity in specific brain regions during a resting state may be associated with the dysfunctions in pain, memory and emotional processing commonly observed in patients with PSPD. These findings help us to understand the neural mechanisms underlying PSPD and suggest that the ReHo metric could be used as a clinical marker for PSPD.
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