ArticleThe American journal of gastroenterology2016
Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of laparoscopic sleeve gastrectomy vs laparoscopic sleeve + Rossetti fundoplication on weight loss and de novo GERD in patients affected by morbid obesity: a randomized clinical study.Obesity surgery · 2022Trial
- A new technique for treating hiatal hernia with gastroesophageal reflux disease: the laparoscopic total left-side surgical approach.BMC surgery · 2021Trial
- Assessment of Vagus Nerve Injury Through Sham Feeding.Digestive diseases and sciences · 2026Article
- Gastrointestinal Complaints After Fundoplication: Rapid Review and Evidence Mapping.Current gastroenterology reports · 2026Review
- Modified laparoscopic Toupet fundoplication with vagus nerve sparing via total left-side approach for hiatal hernia with gastroesophageal reflux disease: a pilot study.Translational gastroenterology and hepatology · 2026Article
- Laparoscopic hyperspectral imaging for in vivo detection of the vagal nerve in upper gastrointestinal surgery.Surgical endoscopy · 2025Article
- Innovative laparoscopic 'Tunnel' approach in managing hiatal hernia with gastroesophageal reflux disease: a retrospective study.BMC surgery · 2025Article
- Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study.JPGN reports · 2024Article
- Dumping Syndrome: Pragmatic Treatment Options and Experimental Approaches for Improving Clinical Outcomes.Clinical and experimental gastroenterology · 2023Review
- Clinical outcomes and functional analysis of third space robotic and endoscopic cooperative surgery versus laparoscopic wedge resection for gastric submucosal tumours: a propensity score-matched study.Updates in surgery · 2022Article
- Magnetic challenge against gastroesophageal reflux.World journal of gastroenterology · 2021Review
- Differential gastric emptiness according to preoperative stomach position in neurological impaired patients who underwent laparoscopic fundoplication and gastrostomy.Surgery today · 2021Article
- Magnetic sphincter augmentation with hiatal hernia repair: long term outcomes.Surgical endoscopy · 2021Article
- Anatomical variation and distribution of the vagus nerve in the esophageal hiatus: a cross-sectional study of post-mortem cases in Uganda.Surgical and radiologic anatomy : SRA · 2021Article
- Laparoscopic total left-sided surgical approach versus traditional bilateral surgical approach for treating hiatal hernia: a study protocol for a randomized controlled trial.Annals of translational medicine · 2021Article
- Impact of vagus nerve integrity testing on surgical management in patients with previous operations with potential risk of vagal injury.Surgical endoscopy · 2019Article
- Posterior fossa arachnoid cyst causing torticollis and gastro-oesophageal reflux in an infant.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Risk factors for delayed gastric emptying following laparoscopic repair of very large hiatus hernias.BJS open · 2017Article
- Quality of life after Nissen fundoplication in patients with gastroesophageal reflux disease: Comparison between long- and short-term follow-up.Journal of minimal access surgeryArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS.
methodsIn the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)).
resultsShort-term follow-up: vagus nerve injury (PP peak ≤47 pmol/l) was observed in 23 patients (18%) 6 months after fundoplication. In both groups, a comparable decrease in reflux parameters and symptoms was observed at 6-month follow-up. Postoperative gastric emptying was significantly delayed in the vagus nerve injury group compared with the vagus nerve intact group. Long-term follow-up: patients with vagus nerve injury showed significantly less effective reflux control and a higher re-operation rate.
conclusionsVagus nerve injury occurs in up to 20% of patients after ARS. Reflux control 6 months after surgery was not affected by vagus nerve injury. However, long-term follow-up showed a negative effect on reflux symptom control and re-operation rate in patients with vagus nerve injury.
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