ArticlePLoS neglected tropical diseases2016
Evolutionary Analysis of Dengue Serotype 2 Viruses Using Phylogenetic and Bayesian Methods from New Delhi, India.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 52 citations in OpenAlex.
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- Molecular epidemiology and evolutionary trends of dengue virus serotype-2 strains in Sri Lanka.BMC microbiology · 2025Article
- Clinico-genomic study reveals association of dengue virus genome high frequency mutations with dengue disease severity.Scientific reports · 2025Article
- Genomic hotspots in the DENV-2 serotype (E, NS4B, and NS5 genes) are associated with dengue disease severity in the endemic region of India.PLoS neglected tropical diseases · 2025Article
- Genotypic diversity and molecular characterization of DENV-2 in a Peruvian endemic region from 2016 to 2022: displacement of American/Asian genotype.Frontiers in microbiology · 2025Article
- Dengue epidemiology and molecular characterization of vector mosquitoes; Aedes aegypti and Aedes albopictus in Mizoram, Northeast India.BMC infectious diseases · 2024Article
- Dengue virus infection during window period of consecutive outbreaks in Nepal and assessment of clinical parameters.Scientific reports · 2023Article
- Evolutionary dynamics of dengue virus in India.PLoS pathogens · 2023Article
- Molecular surveillance of dengue virus in field-collectedFrontiers in microbiology · 2023Article
- Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus.Animal models and experimental medicine · 2022Review
- Three highly variable genome regions of the four dengue virus serotypes can accurately recapitulate the CDS phylogeny.MethodsX · 2022Article
- Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2.Scientific reports · 2021Article
- Molecular characterization of structural protein genes of dengue virus serotype 1 epidemic in Yunnan, Southwest China, in 2018.Archives of virology · 2021Article
- Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019.Pathogens (Basel, Switzerland) · 2020Article
- Molecular and evolutionary analysis of dengue virus serotype 2 isolates from Korean travelers in 2015.Archives of virology · 2020Article
- Genome-Scale Phylogeny and Evolutionary Analysis of Ross River Virus Reveals Periodic Sweeps of Lineage Dominance in Western Australia, 1977-2014.Journal of virology · 2020Article
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- Molecular phylogeny and distribution of dengue virus serotypes circulating in Nepal in 2017.PloS one · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue fever is the most important arboviral disease in the tropical and sub-tropical countries of the world. Delhi, the metropolitan capital state of India, has reported many dengue outbreaks, with the last outbreak occurring in 2013. We have recently reported predominance of dengue virus serotype 2 during 2011-2014 in Delhi. In the present study, we report molecular characterization and evolutionary analysis of dengue serotype 2 viruses which were detected in 2011-2014 in Delhi. Envelope genes of 42 DENV-2 strains were sequenced in the study. All DENV-2 strains grouped within the Cosmopolitan genotype and further clustered into three lineages; Lineage I, II and III. Lineage III replaced lineage I during dengue fever outbreak of 2013. Further, a novel mutation Thr404Ile was detected in the stem region of the envelope protein of a single DENV-2 strain in 2014. Nucleotide substitution rate and time to the most recent common ancestor were determined by molecular clock analysis using Bayesian methods. A change in effective population size of Indian DENV-2 viruses was investigated through Bayesian skyline plot. The study will be a vital road map for investigation of epidemiology and evolutionary pattern of dengue viruses in India.
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