ArticleeLife2016
Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 94 citations in OpenAlex.
- A ∼18 kb upstream deletion of H2AFY is associated with the feathered leg trait in Yanying chickens.Poultry science · 2026Article
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Genomics of Experimental Adaptive Radiation in the Cryptic Coloration of Feather Lice.Genome biology and evolution · 2025Article
- Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens.Poultry science · 2025Article
- A comprehensive study of Z-DNA density and its evolutionary implications in birds.BMC genomics · 2024Article
- A chromosome-level genome assembly of the Asian house martin implies potential genes associated with the feathered-foot trait.G3 (Bethesda, Md.) · 2024Article
- Cellular structure of dinosaur scales reveals retention of reptile-type skin during the evolutionary transition to feathers.Nature communications · 2024Article
- Assembly and annotation of 2 high-quality columbid reference genomes from sequencing of a Columba livia × Columba guinea F1 hybrid.G3 (Bethesda, Md.) · 2024Article
- New findings on the genetic basis of feathered legs in chickens: association of CUBN gene mutations with feathered-leg phenotype.Journal of animal science · 2024Article
- An allelic series at the EDNRB2 locus controls diverse piebalding patterns in the domestic pigeon.PLoS genetics · 2023Article
- Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.Science advances · 2023Article
- Article
- A large deletion at the cortex locus eliminates butterfly wing patterning.G3 (Bethesda, Md.) · 2022Article
- Whole-genome sequencing reveals the artificial selection and local environmental adaptability of pigeons (Evolutionary applications · 2022Article
- Comparative Genomics and Evolution of Avian Specialized Traits.Current genomics · 2021Review
- Cell-specific alterations in Pitx1 regulatory landscape activation caused by the loss of a single enhancer.Nature communications · 2021Article
- Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).Molecular biology and evolution · 2021Article
- A ROR2 coding variant is associated with craniofacial variation in domestic pigeons.Current biology : CB · 2021Article
- Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons.Evolution & development · 2021Article
- Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects.Development (Cambridge, England) · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Birds display remarkable diversity in the distribution and morphology of scales and feathers on their feet, yet the genetic and developmental mechanisms governing this diversity remain unknown. Domestic pigeons have striking variation in foot feathering within a single species, providing a tractable model to investigate the molecular basis of skin appendage differences. We found that feathered feet in pigeons result from a partial transformation from hindlimb to forelimb identity mediated by cis-regulatory changes in the genes encoding the hindlimb-specific transcription factor Pitx1 and forelimb-specific transcription factor Tbx5. We also found that ectopic expression of Tbx5 is associated with foot feathers in chickens, suggesting similar molecular pathways underlie phenotypic convergence between these two species. These results show how changes in expression of regional patterning genes can generate localized changes in organ fate and morphology, and provide viable molecular mechanisms for diversity in hindlimb scale and feather distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.