ArticleMolecular metabolism2016
Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits.
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Maternal supplementation with chia oil attenuates hepatic metabolic disturbances in mice subjected to postnatal undernutrition.Frontiers in nutrition · 2025Article
- Experimental biology can inform our understanding of food insecurity.The Journal of experimental biology · 2024Article
- The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology.Molecular metabolism · 2023Article
- Stimulation of GHRH Neuron Axon Growth by Leptin and Impact of Nutrition during Suckling in Mice.Nutrients · 2023Article
- Development of "Hunger Neurons" and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions.Biological psychiatry · 2022Review
- Central Neurocircuits Regulating Food Intake in Response to Gut Inputs-Preclinical Evidence.Nutrients · 2021Review
- The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.Frontiers in physiology · 2021Review
- Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice.Nutrients · 2020Article
- Differential Responses of Liver and Hypothalamus to the Nutritional Condition During Lactation and Adult Life.Frontiers in physiology · 2020Article
- Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice.Science translational medicine · 2020Article
- Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons.Physiology & behavior · 2019Article
- Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice.Frontiers in endocrinology · 2019Article
- The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition.IBRO reports · 2018Article
- Feeding circuit development and early-life influences on future feeding behaviour.Nature reviews. Neuroscience · 2018Review
- Obesity Pathogenesis: An Endocrine Society Scientific Statement.Endocrine reviews · 2017Review
- HSD2 neurons in the hindbrain drive sodium appetite.Nature neuroscience · 2017Article
- The role of leptin in health and disease.Temperature (Austin, Tex.) · 2017Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveHumans and animals exposed to undernutrition (UN) during development often experience accelerated "catch-up" growth when food supplies are plentiful. Little is known about the mechanisms regulating early growth rates. We previously reported that actions of leptin and presynaptic inputs to orexigenic NPY/AgRP/GABA (NAG) neurons in the arcuate nucleus of the hypothalamus are almost exclusively excitatory during the lactation period, since neuronal and humoral inhibitory systems do not develop until after weaning. Moreover, we identified a critical step that regulates the maturation of electrophysiological responses of NAG neurons at weaning - the onset of genes encoding ATP-dependent potassium (KATP) channel subunits. We explored the possibility that UN promotes subsequent catch-up growth, in part, by delaying the maturation of negative feedback systems to neuronal circuits driving food intake.
methodsWe used the large litter (LL) size model to study the impacts of postnatal UN followed by catch-up growth. We evaluated the maturation of presynaptic and postsynaptic inhibitory systems in NAG neurons using a combination of electrophysiological and molecular criteria, in conjunction with leptin's ability to suppress fasting-induced hyperphagia.
resultsThe onset of KATP channel subunit expression and function, the switch in leptin's effect on NAG neurons, the ingrowth of inhibitory inputs to NAG neurons, and the development of homeostatic feedback to feeding circuits were delayed in LL offspring relative to controls. The development of functional KATP channels and the establishment of leptin-mediated suppression of food intake in the peri-weaning period were tightly linked and were not initiated until growth and adiposity of LL offspring caught up to controls.
conclusionsOur data support the idea that initiation of KATP channel subunit expression in NAG neurons serves as a molecular gatekeeper for the maturation of homeostatic feeding circuits.
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Registered trials
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