Evidence map›Paper›PMID 26977369›Full record

ArticleBiomedical optics express2016

Multimodal 3D cancer-mimicking optical phantom.

Gennifer T Smith, Kristen L Lurie, Dimitar V Zlatev, Joseph C Liao, Audrey K Ellerbee Bowden

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. 3D printing in urology: Is it really promising?Turkish journal of urology · 2018
    Review
  9. Article
  10. Formulation of image fusion as a constrained least squares optimization problem.Journal of medical imaging (Bellingham, Wash.) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gennifer T SmithDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Kristen L LurieDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Dimitar V ZlatevDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Joseph C LiaoDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Audrey K Ellerbee BowdenDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Stanford University · USVA Palo Alto Health Care System · US

Funding

Optical Imaging of Bladder Cancer with Molecular Contrast AgentsR01CA160986 · NCI · STANFORD UNIVERSITY · PI LIAO, JOSEPH C · 2011 to 2014
$1.7M
NCI NIH HHS R01 CA160986
6 · The paper itself

Abstract

Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a real organ under multiple imaging modalities. We demonstrate the utility of the material and technique by fabricating the first 3D, hollow bladder phantom with realistic normal and multi-stage pathology features suitable for endoscopic detection using the gold standard imaging technique, white light cystoscopy (WLC), as well as the complementary imaging modalities of optical coherence tomography and blue light cystoscopy, which are aimed at improving the sensitivity and specificity of WLC to bladder cancer detection. The flexibility of the material and technique used for phantom construction allowed for the representation of a wide range of diseased tissue states, ranging from inflammation (benign) to high-grade cancerous lesions. Such phantoms can serve as important tools for trainee education and evaluation of new endoscopic instrumentation.

Indexed as

(110.4500) Optical coherence tomography(160.4760) Optical properties(170.3880) Medical and biological imaging(170.7230) Urology

Identifiers

PMID26977369
PMCPMC4771478
OpenAlexW2255646529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.