ReviewNeural plasticity2016
Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness.
Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global impact of the COVID-19 pandemic on mental health services: A systematic review.Journal of psychiatric research · 2022Pooled it
- A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.European psychiatry : the journal of the Association of European Psychiatrists · 2021Pooled it
- A Universal Digital Stress Management Intervention for Employees: Randomized Controlled Trial with Health-Economic Evaluation.Journal of medical Internet research · 2024Trial
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Trauma Profiles and Cocaine Use Among Formerly Incarcerated Black Men Who Co-Use Opioids and Stimulants.The Journal of black psychology · 2026Article
- Validating the Chronic Stress Indicator: A Data-Driven Framework for Integrating Physiological and Socio-Behavioral Measures.Measurement : interdisciplinary research and perspectives · 2026Article
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- From Sensation to Anxiety: The Mediating Effect of Physical Sensation and Experiential Avoidance on Exercise Anxiety Among College Students.European journal of sport science · 2026Article
- Anxiety and depression symptoms in relation to body mass index, fruit and vegetable intake, and physical activity among nutrition students in Peru: a cross-sectional study.Frontiers in nutrition · 2026Article
- Editorial: Brain-body interactions underlying comorbid depression and other mood disorders.Frontiers in psychiatry · 2026Article
- Metabolic regulation of behavior by the intestinal enzyme FMO-2.Science advances · 2025Article
- Stroke Care in Conflict and War Zones -Peace Saves Lives!Current neurology and neuroscience reports · 2025Review
- Osteogenesis imperfecta and the family: A qualitative analysis of the experiences of family and caregivers.Families, systems & health : the journal of collaborative family healthcare · 2025Article
- Exploring Interindividual Variability in Resilience to Stress: Social Support, Coping Styles, and Diurnal Cortisol in Older Adults.Behavioral sciences (Basel, Switzerland) · 2025Article
- Third-Generation Antipsychotics: The Quest for the Key to Neurotrophism.Life (Basel, Switzerland) · 2025Review
- Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System.Biomedicines · 2025Review
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- Impact of war on stroke incidence in Ivano-Frankivsk, Ukraine.Scientific reports · 2024Article
- Demand for mental health support services among health professionals in Vietnam: Lesson from COVID-19 Pandemic.PloS one · 2024Article
- Increasing stress resilience in older adults through a 6-week prevention program: effects on coping strategies, anxiety symptoms, and cortisol levels.Frontiers in psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Neuropsychiatric symptoms and mental illness are commonly present in patients with chronic systemic diseases. Mood disorders, such as depression, are present in up to 50% of these patients, resulting in impaired physical recovery and more intricate treatment regimen. Stress associated with both physical and emotional aspects of systemic illness is thought to elicit detrimental effects to initiate comorbid mental disorders. However, clinical reports also indicate that the relationship between systemic and psychiatric illnesses is bidirectional, further increasing the complexity of the underlying pathophysiological processes. In this review, we discuss the recent evidence linking chronic stress and systemic illness, such as activation of the immune response system and release of common proinflammatory mediators. Altogether, discovery of new targets is needed for development of better treatments for stress-related psychiatric illnesses as well as improvement of mental health aspects of different systemic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.