ArticleJournal of tissue engineering
Design of barrier coatings on kink-resistant peripheral nerve conduits.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Mechanistic Advancements and Translational Progress in Hyaluronic Acid-Based Scaffolds and Conduits for Peripheral Nerve Regeneration.Journal of functional biomaterials · 2025Review
- Mesenchymal stem cell-laden double-network hydrogel nerve guidance conduits for peripheral nerve injury repair.Bioactive materials · 2025Article
- Engineering the Future of Restorative Clinical Peripheral Nerve Surgery.Advanced healthcare materials · 2025Review
- Longitudinally aligned inner-patterned silk fibroin conduits for peripheral nerve regeneration.In vitro models · 2023Article
- Thermoelectric Freeze-Casting of Biopolymer Blends: Fabrication and Characterization of Large-Size Scaffolds for Nerve Tissue Engineering Applications.Journal of functional biomaterials · 2023Article
- Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization.Biomedical materials & devices (New York, N.Y.) · 2023Article
- Improvement of sciatic nerve regeneration by multichannel nanofibrous membrane-embedded electro-conductive conduits functionalized with laminin.Journal of materials science. Materials in medicine · 2022Article
- Thermal Processing of a Degradable Carboxylic Acid-Functionalized Polycarbonate into Scaffolds for Tissue Engineering.Polymer engineering and science · 2021Article
- Natural-Based Biomaterials for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2020Review
- Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats.Frontiers in bioengineering and biotechnology · 2020Article
- Engineering nerve guidance conduits with three-dimenisonal bioprinting technology for long gap peripheral nerve regeneration.Neural regeneration research · 2019Article
- Localized delivery of immunosuppressive regulatory T cells to peripheral nerve allografts promotes regeneration of branched segmental defects.Biomaterials · 2019Article
- Preparation of high-performance polyethylene tubes under the coexistence of silicone cross-linked polyethylene and rotation extrusion.Royal Society open science · 2019Article
- Aligned fibers enhance nerve guide conduits when bridging peripheral nerve defects focused on early repair stage.Neural regeneration research · 2019Article
- Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration.International journal of molecular sciences · 2017Article
- Fibrin glue as a stabilization strategy in peripheral nerve repair when using porous nerve guidance conduits.Journal of materials science. Materials in medicine · 2017Article
- Effects of Terminal Sterilization on PEG-Based Bioresorbable Polymers Used in Biomedical Applications.Macromolecular materials and engineering · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings allowed cellular infiltration that limited nerve recovery. Several types of secondary barrier coatings were tested in animal studies, including (1) electrospinning a layer of polymer fibers onto the surface of the conduit and (2) coating the conduit with a cross-linked hyaluronic acid-based hydrogel. Sixteen weeks after implantation, hyaluronic acid-coated conduits had higher axonal density, displayed higher muscle weight, and better electrophysiological signal recovery than uncoated conduits or conduits having an electrospun layer of polymer fibers. This study indicates that braiding is a promising method of fabrication to improve the mechanical properties of peripheral nerve conduits and demonstrates the need to control the porosity of the conduit wall to optimize functional nerve recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.