Evidence map›Paper›PMID 26977284›Full record

ReviewJournal of tissue engineering

Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues.

Hye-Sun Yu, Jung-Ju Kim, Hae-Won Kim, Mark P Lewis, Ivan Wall

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. The mechanical forces that shape our senses.Development (Cambridge, England) · 2022
    Review
  14. Article
  15. Auricular reconstruction: where are we now? A critical literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Review
  16. Article
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  18. Article
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  20. Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hye-Sun YuDepartment of Biochemical Engineering, University College London, London, UK; Department of Nanobiomedical Science and BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea.
Jung-Ju KimDepartment of Nanobiomedical Science and BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea.
Hae-Won KimDepartment of Nanobiomedical Science and BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea; Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, South Korea.
Mark P LewisMusculo-Skeletal Biology Research Group, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Ivan WallDepartment of Biochemical Engineering, University College London, London, UK; Department of Nanobiomedical Science and BK21 Plus NBM Global Research Center for Regenerative Medicine, Dankook University Graduate School, Cheonan, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations.

Indexed as

bonecartilageFlexercellligamentmechanical strainmuscletendon

Identifiers

PMID26977284
PMCPMC4765821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.