ArticleThe Plant cell2016
Functionally Similar WRKY Proteins Regulate Vacuolar Acidification in Petunia and Hair Development in Arabidopsis.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 160 citations in OpenAlex.
- WRKY14-DPB Module Enhances Drought Tolerance by Activating the Expression of UGT84B1 Involved in Hydrolyzable Tannin Biosynthesis.Plant, cell & environment · 2026Article
- Spatial control of anthocyanin and proanthocyanidin production in tomato fruits by competitive MBW complexes to promote seed dispersal.Plant communications · 2026Article
- Positional grammar of transcription factor binding partitions developmental and stress-response regulation in plants.Nature communications · 2026Article
- Pangenome Analysis Reveals Structural Variations Associated With Citric Acid Accumulation in Prunus mume.Plant biotechnology journal · 2026Article
- Deciphering the Biosynthetic Pathways and Regulatory Networks of the Active Components ofInternational journal of molecular sciences · 2026Article
- Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Diversity and ecological functions of anthocyanins.BMC plant biology · 2025Review
- Polyacylated Delphinidin Biosynthesis Catalysed by PhF3'5'H-PhBGLU12-PhSCPL2 Determines the Blue Pigmentation in Cineraria (Pericallis hybrida).Plant biotechnology journal · 2025Article
- The VvWRKY26-MBW Complex Induced by Salicylic Acid Promotes the Accumulation of Proanthocyanidins in Grape.Plants (Basel, Switzerland) · 2025Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- WRKYs as regulatory hubs of secondary metabolic networks: Diverse inducers and distinct responses.Plant communications · 2025Review
- Physiological and biochemical basis of flower coloration in Aquilegia oxysepala with a functional study of AoDFR08.BMC plant biology · 2025Article
- RsWRKY44 participated in anthocyanin biosynthesis regulation in radish through interaction with RsMYB1a.Plant cell reports · 2025Article
- AP2 transcription factor CsAIL6 negatively regulates citric acid accumulation in citrus fruits by interacting with a WD40 protein CsAN11.Horticulture research · 2025Article
- Integrated transcriptomic and metabolomic analyses reveal the molecular mechanism of flower color differentiation inFrontiers in plant science · 2025Article
- Genome-Wide Identification and Characterization of theEvolutionary bioinformatics online · 2025Article
- A Functional InDel in the WRKY10 Promoter Controls the Degree of Flesh Red Pigmentation in Apple.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Identification of tomato F-box proteins functioning in phenylpropanoid metabolism.Plant molecular biology · 2024Article
- VvWRKY5 positively regulates wounding-induced anthocyanin accumulation in grape by interplaying with VvMYBA1 and promoting jasmonic acid biosynthesis.Horticulture research · 2024Article
- Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.Scientific reports · 2024Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WD40 proteins ANTHOCYANIN11 (AN11) from petunia (Petunia hybrida) and TRANSPARENT TESTA GLABRA1 (TTG1) from Arabidopsis thaliana and associated basic helix-loop-helix (bHLH) and MYB transcription factors activate a variety of differentiation processes. In petunia petals, AN11 and the bHLH protein AN1 activate, together with the MYB protein AN2, anthocyanin biosynthesis and, together with the MYB protein PH4, distinct genes, such as PH1 and PH5, that acidify the vacuole. To understand how AN1 and AN11 activate anthocyanin biosynthetic and PH genes independently, we isolated PH3. We found that PH3 is a target gene of the AN11-AN1-PH4 complex and encodes a WRKY protein that can bind to AN11 and is required, in a feed-forward loop, together with AN11-AN1-PH4 for transcription of PH5. PH3 is highly similar to TTG2, which regulates hair development, tannin accumulation, and mucilage production in Arabidopsis. Like PH3, TTG2 can bind to petunia AN11 and the Arabidopsis homolog TTG1, complement ph3 in petunia, and reactivate the PH3 target gene PH5. Our findings show that the specificity of WD40-bHLH-MYB complexes is in part determined by interacting proteins, such as PH3 and TTG2, and reveal an unanticipated similarity in the regulatory circuitry that controls petunia vacuolar acidification and Arabidopsis hair development.
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