Evidence map›Paper›PMID 26976915›Full record

ReviewCirculation2016

Shared Risk Factors in Cardiovascular Disease and Cancer.

Ryan J Koene, Anna E Prizment, Anne Blaes, Suma H Konety

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 834 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
834citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

834 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  7. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  8. A Systematic Review of Cardiovascular Health Among Cancer Survivors.International journal of environmental research and public health · 2025
    Pooled it
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  14. Review
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  19. The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  20. High incidence of colorectal cancer in Japanese individuals with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article

774 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan J KoeneFrom Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.). koene030@umn.edu.
Anna E PrizmentFrom Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.).
Anne BlaesFrom Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.).
Suma H KonetyFrom Department of Medicine, Division of Cardiovascular Medicine, University of Minnesota, Minneapolis (R.J.K., S.H.K.); Department of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.E.P.); Department of Medicine, Division of Oncology, University of Minnesota, Minneapolis (A.B.); and Masonic Cancer Center, University of Minnesota, Minneapolis (A.E.P.).

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide. Although commonly thought of as 2 separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (eg, obesity, diabetes mellitus), suggesting a shared biology for which there is emerging evidence. Although chronic inflammation is an indispensable feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, with millions of cancer survivors now at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them.

Indexed as

AdultAgedAge FactorsAlcohol DrinkingAnticarcinogenic AgentsAntihypertensive AgentsAnti-Inflammatory Agents, Non-SteroidalCardiovascular DiseasesComorbidityDiabetes MellitusDietFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperinsulinismHyperlipidemiasAnticarcinogenic AgentsAntihypertensive AgentsAnti-Inflammatory Agents, Non-SteroidalHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic Agentscardiologycardiovascular diseasesclinical oncologyrisk factors

Identifiers

PMID26976915
PMCPMC4800750

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.