Evidence map›Paper›PMID 26976890›Full record

ArticleThe American journal of tropical medicine and hygiene2016

Local Production of a Liquid Direct Agglutination Test as a Sustainable Measure for Control of Visceral Leishmaniasis in Sudan.

Hussam Ali Osman, Abdelhafeiz Mahamoud, Elfadil Mustafa Abass, Rubens Riscala Madi, Saul J Semiao-Santos, Abdallah El Harith

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Diagnosis and Causative Species of Visceral Leishmaniasis in Southwest Saudi Arabia.The American journal of tropical medicine and hygiene · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hussam Ali OsmanBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil.
Abdelhafeiz MahamoudBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil.
Elfadil Mustafa AbassBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil.
Rubens Riscala MadiBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil.
Saul J Semiao-SantosBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil saulix@gmail.com.
Abdallah El HarithBiomedical Research Laboratory, Ahfad University for Women, Omdurman, Sudan; Department of Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan; Postgraduate Program in Health and Environment, University of Tiradentes, Aracaju, Sergipe, Brazil; Department of Medicine and Nursing, University of Tiradentes, Aracaju, Sergipe, Brazil.
Universidade Tiradentes · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A prerequisite for the control of visceral leishmaniasis (VL) is the accessibility to reference diagnostics. The high price of the freeze-dried direct agglutination test (FD-DAT) and the short shelf-life time of the rK39 strip test (rK39) have limited the application of these tests in Sudan. An original liquid DAT (LQ-DAT) with high reproducibility compared with the FD-DAT and rK39 has been routinely produced in our laboratory since 1999. In this study, a 3.4-year-old batch (of more than 90 test batches produced to date) was chosen to validate the diagnostic performance of this test against microscopy, FD-DAT, and rK39 in 96 VL and 42 non-VL serum samples. Relatively higher sensitivity (95/96, 99.0%) was recorded for the LQ-DAT than for the FD-DAT (92/96, 95.8%) and rK39 (76/96, 79.2%), probably because of the use of the endemic autochthonous Leishmania donovani isolate as the antigen. Experience with the LQ-DAT, its low cost of production, ease of providing this test, and diagnostic reliability compared with the FD-DAT suggest that widescale implementation of the LQ-DAT can contribute to sustainable VL control in Sudan.

Indexed as

Agglutination TestsHumansLeishmaniasis, VisceralReproducibility of ResultsSensitivity and SpecificitySudan

Identifiers

PMID26976890
PMCPMC4856630
OpenAlexW2301721850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.