Evidence map›Paper›PMID 26976734›Full record

Trial reportGut2017

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.

Keith McIntosh, David E Reed, Theresa Schneider, Frances Dang, Ammar H Keshteli, Giada De Palma, Karen Madsen, Premysl Bercik, Stephen Vanner

Erratum issued 3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 206 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 11 pooled it
40.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01829932 nacompletednot on this map

The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study

TypeinterventionalSponsorQueen's UniversityRan2013 to 2014Enrolled30ConditionsIrritable Bowel SyndromeArmsFactor Altered Diet
NCT03221790 naunknown statusnot on this map

A Study Evaluating the Effects of Low and High FODMAP Diets on Mucosal Protease Nerve Interactions in IBS Patients

TypeinterventionalSponsorQueen's UniversityRan2017 to 2019Enrolled20ConditionsIrritable Bowel Syndrome With DiarrheaArmsLow FODMAP Diet followed by a High FODMAP Diet
NCT03653689 nacompletednot on this mapstarted 2018, after this paper: background citation

Molecular Phenotyping of IBS Subtypes

TypeinterventionalSponsorUppsala UniversityRan2018 to 2019Enrolled110ConditionsIrritable Bowel SyndromeArmsFODMAP, Gluten, Placebo
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 11 syntheses or guidelines pooled it, 480 citations in OpenAlex.

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  4. Efficacy of a Restrictive Diet in Irritable Bowel Syndrome: A Systematic Review and Network Meta-analysis.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Keith McIntoshGI Diseases Research Unit, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
David E ReedGI Diseases Research Unit, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
Theresa SchneiderGI Diseases Research Unit, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
Frances DangGI Diseases Research Unit, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
Ammar H KeshteliUniversity of Alberta, Edmonton, Alberta, Canada.
Giada De PalmaFarmcombe Institute, McMaster University, Hamilton, Ontario, Canada.
Karen MadsenUniversity of Alberta, Edmonton, Alberta, Canada.
Premysl BercikFarmcombe Institute, McMaster University, Hamilton, Ontario, Canada.
Stephen VannerGI Diseases Research Unit, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
Kingston General Hospital · CAMcMaster University · CAUniversity of Alberta · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS.

designWe performed a controlled, single blind study of patients with IBS (Rome III criteria) randomised to a low (n=20) or high (n=20) FODMAP diet for 3 weeks. Symptoms were assessed using the IBS symptom severity scoring (IBS-SSS). The metabolome was evaluated using the lactulose breath test (LBT) and metabolic profiling in urine using mass spectrometry. Stool microbiota composition was analysed by 16S rRNA gene profiling.

resultsThirty-seven patients (19 low FODMAP; 18 high FODMAP) completed the 3-week diet. The IBS-SSS was reduced in the low FODMAP diet group (p<0.001) but not the high FODMAP group. LBTs showed a minor decrease in H

conclusionsIBS symptoms are linked to FODMAP content and associated with alterations in the metabolome. In subsets of patients, FODMAPs modulate histamine levels and the microbiota, both of which could alter symptoms. TRIAL REGISTRATION NUMBER: NCT01829932.

Indexed as

DietAdultAgedAged, 80 and overBreath TestsDicarboxylic AcidsFecesFemaleGastrointestinal MicrobiomeHistamineHumansIrritable Bowel SyndromeLactuloseMaleMetabolomeMiddle Aged4-hydroxybenzoic acidazelaic acidDicarboxylic AcidsHistamineLactuloseParabensCARBOHYDRATESCOLONIC MICROFLORAHISTAMINEIRRITABLE BOWEL SYNDROME

Identifiers

PMID26976734
OpenAlexW2300077111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.