ArticleJournal of neuroscience methods2016
The supination assessment task: An automated method for quantifying forelimb rotational function in rats.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Advice for translational neuroscience: move deliberately and build things.Bioelectronic medicine · 2025Article
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- AutoRG: An automatized reach-to-grasp platform technology for assessing forelimb motor function, neural circuit activation, and cognition in rodents.Journal of neuroscience methods · 2023Article
- Vagus nerve stimulation does not improve recovery of forelimb motor or somatosensory function in a model of neuropathic pain.Scientific reports · 2022Article
- Automated Forelimb Tasks for Rodents: Current Advantages and Limitations, and Future Promise.Neurorehabilitation and neural repair · 2019Article
- Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury.eLife · 2018Article
- Vagus Nerve Stimulation Enhances Stable Plasticity and Generalization of Stroke Recovery.Stroke · 2018Article
- Plasticity in One Hemisphere, Control From Two: Adaptation in Descending Motor Pathways After Unilateral Corticospinal Injury in Neonatal Rats.Frontiers in neural circuits · 2018Article
- The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats.Journal of visualized experiments : JoVE · 2017Article
- Dexterity: A MATLAB-based analysis software suite for processing and visualizing data from tasks that measure arm or forelimb function.Journal of neuroscience methods · 2017Article
- Investigating Motor Skill Learning Processes with a Robotic Manipulandum.Journal of visualized experiments : JoVE · 2017Article
- Radial nerve injury causes long-lasting forelimb sensory impairment and motor dysfunction in rats.Pain reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNeurological injuries or disease can impair the function of motor circuitry controlling forearm supination, and recovery is often limited. Preclinical animal models are essential tools for developing therapeutic interventions to improve motor function after neurological damage. Here we describe the supination assessment task, an automated measure of quantifying forelimb supination in the rat. NEW
methodAnimals were trained to reach out of a slot in a cage, grasp a spherical manipulandum, and supinate the forelimb. The angle of the manipulandum was measured using a rotary encoder. If the animal exceeded the predetermined turn angle, a reward pellet was delivered. This automated task provides a large, high-resolution dataset of turn angle over time. Multiple parameters can be measured including success rate, peak turn angle, turn velocity, area under the curve, and number of rotations per trial. The task provides a high degree of flexibility to the user, with both software and hardware parameters capable of being adjusted.
resultsWe demonstrate the supination assessment task can effectively measure significant deficits in multiple parameters of rotational motor function for multiple weeks in two models of ischemic stroke. COMPARISON WITH EXISTING
methodsPreexisting motor assays designed to measure forelimb supination in the rat require high-speed video analysis techniques. This operant task provides a high-resolution, quantitative end-point dataset of turn angle, which obviates the necessity of video analysis.
conclusionsThe supination assessment task represents a novel, efficient method of evaluating forelimb rotation and may help decrease the cost and time of running experiments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.