Evidence map›Paper›PMID 26976647›Full record

ReviewThe Lancet. Neurology2016

Neurocognitive factors in sensory restoration of early deafness: a connectome model.

Andrej Kral, William G Kronenberger, David B Pisoni, Gerard M O'Donoghue

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 5 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 5 syntheses or guidelines pooled it, 360 citations in OpenAlex.

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  8. Determinants of auditory performance after cochlear implantation in post-lingual adults: beyond the duration of hearing loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Andrej KralInstitute of AudioNeuroTechnology and Department of Experimental Otology, ENT Clinics, Medical University Hannover, Hannover, Germany; School of Behavioural and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA. Electronic address: kral.andrej@mh-hannover.de.
William G KronenbergerDepartment of Psychiatry, and DeVault Otologic Research Laboratory, Department of Otolaryngology: Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Indianapolis, IN, USA.
David B PisoniDepartment of Psychiatry, and DeVault Otologic Research Laboratory, Department of Otolaryngology: Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Indianapolis, IN, USA.
Gerard M O'DonoghueNational Institute of Health Research, Nottingham Hearing Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineNottingham University Hospitals NHS Trust · GBThe University of Texas at Dallas · US

Funding

SPEECH PERCEPTION &SPOKEN WORD RECOGNITIONR01DC000111 · NIDCD · TRUSTEES OF INDIANA UNIVERSITY · PI PISONI, DAVID B · 1989 to 2015
$8.1M
Neurocognitive Processes in Deaf Children with Cochlear ImplantsR01DC009581 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI PISONI, DAVID B · 2009 to 2013
$3.0M
NIDCD NIH HHS R01 DC000111
6 · The paper itself

Abstract

Progress in biomedical technology (cochlear, vestibular, and retinal implants) has led to remarkable success in neurosensory restoration, particularly in the auditory system. However, outcomes vary considerably, even after accounting for comorbidity-for example, after cochlear implantation, some deaf children develop spoken language skills approaching those of their hearing peers, whereas other children fail to do so. Here, we review evidence that auditory deprivation has widespread effects on brain development, affecting the capacity to process information beyond the auditory system. After sensory loss and deafness, the brain's effective connectivity is altered within the auditory system, between sensory systems, and between the auditory system and centres serving higher order neurocognitive functions. As a result, congenital sensory loss could be thought of as a connectome disease, with interindividual variability in the brain's adaptation to sensory loss underpinning much of the observed variation in outcome of cochlear implantation. Different executive functions, sequential processing, and concept formation are at particular risk in deaf children. A battery of clinical tests can allow early identification of neurocognitive risk factors. Intervention strategies that address these impairments with a personalised approach, taking interindividual variations into account, will further improve outcomes.

Indexed as

ConnectomeBrainChildConcept FormationDeafnessDevelopmental DisabilitiesExecutive FunctionHumans

Identifiers

PMID26976647
PMCPMC6260790
OpenAlexW2296381011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.