ArticleProceedings of the National Academy of Sciences of the United States of America2016
Phasic, suprathreshold excitation and sustained inhibition underlie neuronal selectivity for short-duration sounds.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Chronic recording of brain activity in awake toads.Journal of neuroscience methods · 2025Article
- How auditory neurons count temporal intervals and decode information.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural basis of acoustic species recognition in a cryptic species complex.The Journal of experimental biology · 2021Article
- Neurogenomic divergence during speciation by reinforcement of mating behaviors in chorus frogs (Pseudacris).BMC genomics · 2021Article
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- How auditory selectivity for sound timing arises: The diverse roles of GABAergic inhibition in shaping the excitation to interval-selective midbrain neurons.Progress in neurobiology · 2021Article
- Article
- 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression.Frontiers in neural circuits · 2021Article
- An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Differential Inhibitory Configurations Segregate Frequency Selectivity in the Mouse Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Short-Term Synaptic Plasticity as a Mechanism for Sensory Timing.Trends in neurosciences · 2018Review
- Inhibitory Neural Circuits in the Mammalian Auditory Midbrain.Journal of experimental neuroscience · 2018Review
- Inhibitory Pathways for Processing the Temporal Structure of Sensory Signals in the Insect Brain.Frontiers in psychology · 2018Review
- Interneurons in the Honeybee Primary Auditory Center Responding to Waggle Dance-Like Vibration Pulses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The numerical abilities of anurans and their neural correlates: insights from neuroethological studies of acoustic communication.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
Sound duration is important in acoustic communication, including speech recognition in humans. Although duration-selective auditory neurons have been found, the underlying mechanisms are unclear. To investigate these mechanisms we combined in vivo whole-cell patch recordings from midbrain neurons, extraction of excitatory and inhibitory conductances, and focal pharmacological manipulations. We show that selectivity for short-duration stimuli results from integration of short-latency, sustained inhibition with delayed, phasic excitation; active membrane properties appeared to amplify responses to effective stimuli. Blocking GABAA receptors attenuated stimulus-related inhibition, revealed suprathreshold excitation at all stimulus durations, and decreased short-pass selectivity without changing resting potentials. Blocking AMPA and NMDA receptors to attenuate excitation confirmed that inhibition tracks stimulus duration and revealed no evidence of postinhibitory rebound depolarization inherent to coincidence models of duration selectivity. These results strongly support an anticoincidence mechanism of short-pass selectivity, wherein inhibition and suprathreshold excitation show greatest temporal overlap for long duration stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.