Evidence map›Paper›PMID 26976545›Full record

ArticleCirculation. Cardiovascular genetics2016

Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association.

Jennifer L Hall, John J Ryan, Bruce E Bray, Candice Brown, David Lanfear, L Kristin Newby, Mary V Relling, Neil J Risch, Dan M Roden, Stanley Y Shaw and 8 more

Abstract read
In one paragraph

Article in Circulation. Cardiovascular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Data Fusion for Partial Identification of Causal Effects.Advances in neural information processing systems · 2025
    Article
  4. Review
  5. Article
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  8. Article
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  14. Article
  15. Precision medicine in cardiology.Nature reviews. Cardiology · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jennifer L Hall
John J Ryan
Bruce E Bray
Candice Brown
David Lanfear
L Kristin Newby
Mary V Relling
Neil J Risch
Dan M Roden
Stanley Y Shaw
James E Tcheng
Jessica Tenenbaum
Thomas N Wang
William S Weintraub
American Heart Association Professional and Public Education and Publications Committee of the Council on Functional Genomics and Translational Biology
Council on Clinical Cardiology
Council on Epidemiology and Prevention
Council on Quality of Care and Outcomes Research, and Stroke Council

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
VGER, the Vanderbilt Genome-Electronic Records ProjectU01HG008672 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., RODEN, DAN M · 2015 to 2019
$5.1M
Estradiol Regulation of Brain-Microvascular Inflammatory Responses in SepsisK01NS081014 · NINDS · WEST VIRGINIA UNIVERSITY · PI BROWN, CANDICE · 2012 to 2016
$714k
Genetic Risk Factors of Myocyte Contractility in Human Heart FailureR21HL104596 · NHLBI · UNIVERSITY OF MINNESOTA · PI HALL, JENNIFER L · 2011 to 2012
$421k
NHGRI NIH HHS U01 HG008672NHLBI NIH HHS R21 HL104596NIGMS NIH HHS U54 GM104941NINDS NIH HHS K01 NS081014
6 · The paper itself

Abstract

The process of scientific discovery is rapidly evolving. The funding climate has influenced a favorable shift in scientific discovery toward the use of existing resources such as the electronic health record. The electronic health record enables long-term outlooks on human health and disease, in conjunction with multidimensional phenotypes that include laboratory data, images, vital signs, and other clinical information. Initial work has confirmed the utility of the electronic health record for understanding mechanisms and patterns of variability in disease susceptibility, disease evolution, and drug responses. The addition of biobanks and genomic data to the information contained in the electronic health record has been demonstrated. The purpose of this statement is to discuss the current challenges in and the potential for merging electronic health record data and genomics for cardiovascular research.

Indexed as

Biomedical ResearchElectronic Health RecordsGenomicsSocieties, MedicalCardiovascular DiseasesData CollectionHumansInformed ConsentPatient CareAHA Scientific Statementselectronic health recordsenvironment and public healthgenetic researchgeneticsgenomics

Identifiers

PMID26976545
PMCPMC5646218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.