ArticleNature2016
Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins.
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 1 of them a synthesis that pooled it.
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Who cites it
178 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Palaeoanthropological evidence from China is changing the picture of hominin evolutionary history.Nature ecology & evolution · 2026Review
- Archaeogenetic insights into the demographic history of Late Neanderthals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Early colonization before inundation consistent with northern glacial refugia in Southern Doggerland revealed by sedimentary ancient DNA.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hypothesis: A modern human range expansion ~300,000 years ago explains Neandertal origins.bioRxiv : the preprint server for biology · 2026Article
- Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans.Science advances · 2026Article
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- Mitochondrial genomes of Middle Pleistocene horses from the open-air site complex of Schöningen.Nature ecology & evolution · 2025Article
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Rethinking Hominin Air Sac Loss in Light of Phylogenetically Meaningful Evidence.Evolutionary anthropology · 2025Article
- A crossroads in the timeline of human evolution.Nature reviews. Genetics · 2025Article
- Whole-genome ancestry of an Old Kingdom Egyptian.Nature · 2025Article
- Genomic data from the extinct California brown bear suggests a source population for reintroduction to California.The Journal of heredity · 2025Article
118 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A unique assemblage of 28 hominin individuals, found in Sima de los Huesos in the Sierra de Atapuerca in Spain, has recently been dated to approximately 430,000 years ago. An interesting question is how these Middle Pleistocene hominins were related to those who lived in the Late Pleistocene epoch, in particular to Neanderthals in western Eurasia and to Denisovans, a sister group of Neanderthals so far known only from southern Siberia. While the Sima de los Huesos hominins share some derived morphological features with Neanderthals, the mitochondrial genome retrieved from one individual from Sima de los Huesos is more closely related to the mitochondrial DNA of Denisovans than to that of Neanderthals. However, since the mitochondrial DNA does not reveal the full picture of relationships among populations, we have investigated DNA preservation in several individuals found at Sima de los Huesos. Here we recover nuclear DNA sequences from two specimens, which show that the Sima de los Huesos hominins were related to Neanderthals rather than to Denisovans, indicating that the population divergence between Neanderthals and Denisovans predates 430,000 years ago. A mitochondrial DNA recovered from one of the specimens shares the previously described relationship to Denisovan mitochondrial DNAs, suggesting, among other possibilities, that the mitochondrial DNA gene pool of Neanderthals turned over later in their history.
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