Evidence map›Paper›PMID 26976443›Full record

ArticleG3 (Bethesda, Md.)2016

Genomic Selection in Multi-environment Crop Trials.

Helena Oakey, Brian Cullis, Robin Thompson, Jordi Comadran, Claire Halpin, Robbie Waugh

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Improved bivariate analysis of canola survivability against blackleg disease.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Genomic selection using random regressions on known and latent environmental covariates.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022
    Article
  10. Sparse testing using genomic prediction improves selection for breeding targets in elite spring wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Overview of Major Computer Packages for Genomic Prediction of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Helena OakeyDivision of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK.
Brian CullisNational Institute for Applied Statistics Research Australia, University of Wollongong, NSW, 2522, Australia.
Robin ThompsonRothamsted Research, Harpenden, Hertfordshire AL5 3JQ, UK.
Jordi ComadranDepartment of Cell and Molecular Sciences, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK.
Claire HalpinDivision of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK c.halpin@dundee.ac.uk r.waugh@dundee.ac.uk.ORCID 0000-0002-1808-8130
Robbie WaughDivision of Plant Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK Department of Cell and Molecular Sciences, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK c.halpin@dundee.ac.uk r.waugh@dundee.ac.uk.
James Hutton Institute · GBAustralian Bureau of Statistics · AURothamsted Research · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G016216/1Biotechnology and Biological Sciences Research Council BB/G016232/1
6 · The paper itself

Abstract

Genomic selection in crop breeding introduces modeling challenges not found in animal studies. These include the need to accommodate replicate plants for each line, consider spatial variation in field trials, address line by environment interactions, and capture nonadditive effects. Here, we propose a flexible single-stage genomic selection approach that resolves these issues. Our linear mixed model incorporates spatial variation through environment-specific terms, and also randomization-based design terms. It considers marker, and marker by environment interactions using ridge regression best linear unbiased prediction to extend genomic selection to multiple environments. Since the approach uses the raw data from line replicates, the line genetic variation is partitioned into marker and nonmarker residual genetic variation (i.e., additive and nonadditive effects). This results in a more precise estimate of marker genetic effects. Using barley height data from trials, in 2 different years, of up to 477 cultivars, we demonstrate that our new genomic selection model improves predictions compared to current models. Analyzing single trials revealed improvements in predictive ability of up to 5.7%. For the multiple environment trial (MET) model, combining both year trials improved predictive ability up to 11.4% compared to a single environment analysis. Benefits were significant even when fewer markers were used. Compared to a single-year standard model run with 3490 markers, our partitioned MET model achieved the same predictive ability using between 500 and 1000 markers depending on the trial. Our approach can be used to increase accuracy and confidence in the selection of the best lines for breeding and/or, to reduce costs by using fewer markers.

Indexed as

EnvironmentGenome, PlantGenomicsQuantitative Trait, HeritableSelection, GeneticAlgorithmsBreedingCrops, AgriculturalGene-Environment InteractionGenetic Association StudiesHigh-Throughput Nucleotide SequencingInheritance PatternsModels, GeneticPhenotypePolymorphism, Single NucleotideQuantitative Trait LocibarleyGEBVgenomic selectionGenPredmulti-environment trialrandom ridge regressionshared data resource

Identifiers

PMID26976443
PMCPMC4856083
OpenAlexW2301286436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.