ArticleThe Korean journal of internal medicine2016
An analysis of age-related loss of skeletal muscle mass and its significance on osteoarthritis in a Korean population.
Article in The Korean journal of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2025Pooled it
- Trial
- The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study.Clinical interventions in aging · 2019Trial
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Association of possible sarcopenia, sarcopenia and knee osteoarthritis among middle-aged and older adults: Evidence from the CHARLS cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Prevalence of osteosarcopenia in patients with end-stage knee OA who underwent total knee arthroplasty.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Chest CT-determined sarcopenia is associated with poorer functional outcomes in osteoarthritis patients undergoing total knee arthroplasty: a retrospective cohort study.Scientific reports · 2025Article
- Short-Term Impact of Low-Intensity Exercise with Blood Flow Restriction on Mild Knee Osteoarthritis in Older Adults: A Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Basal metabolic rate mediates the causal relationship between gut microbiota and osteoarthritis: a two-step bidirectional Mendelian randomization study.Frontiers in microbiology · 2024Article
- The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study.BMC medical genomics · 2023Article
- Article
- A Bidirectional Mendelian Randomization Study of Sarcopenia-Related Traits and Knee Osteoarthritis.Clinical interventions in aging · 2023Review
- Correlation between Mild Cognitive Impairment and Sarcopenia: The Prospective Role of Lipids and Basal Metabolic Rate in the Link.Nutrients · 2022Article
- Article
- Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study.Frontiers in endocrinology · 2021Article
- Impact of sarcopenia on rehabilitation outcomes after total knee replacement in older adults with knee osteoarthritis.Therapeutic advances in musculoskeletal disease · 2021Article
- Association of leg muscle symmetry with knee osteoarthritis.Clinical rheumatology · 2019Article
- Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Fat-to-Muscle Ratio: A New Anthropometric Indicator as a Screening Tool for Metabolic Syndrome in Young Colombian People.Nutrients · 2018Article
- Public Health issues in hospital management of Sarcopenic patients.Journal of frailty, sarcopenia and falls · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThis study was conducted in order to analyze the effects of sarcopenia on age-related osteoarthritis (OA) of the knee in a Korean population.
methodsAll the Korean subjects who visited the Yeungnam University Medical Center Health Promotion Center between 2008 and 2012 in order to undergo a routine medical examination were enrolled. A total of 5,723 young, healthy people (2,959 males, 2,764 females) enrolled as normal subjects and 23,473 subjects (13,006 males and 10,467 females) were included for evaluation of the effects of sarcopenia on OA. There were 266 subjects who followed-up bioelectrical impedance analysis at a 4-year interval. Of 327 subjects enrolled in this study, knees with anteroposterior X-rays were assessed according to the Kellgren-Lawrence (K/L) grade.
resultsSkeletal muscle mass index (SMI) and basal metabolic rate (BMR) showed a steady decrease with the advance of age (p < 0.01), but SMI showed strong positive correlation with BMR (r = 0.72, β = 30.96, p < 0.01). During the 4-year interval, BMR showed a significant decrease with aging (p < 0.01), consistently with the decrease of SMI. Knees with normal SMI were prone to be designated as K/L grade 0 or 1; however, subjects with sarcopenia showed a trend toward the higher K/L grade, classified as knee radiological osteoarthritis (ROA) (p < 0.01).
conclusionsThe results of this study may indicate that sarcopenia as age-related loss of skeletal muscle mass is interactively correlated with the presence and severity of age-related OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.