ArticleProceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine2016
Sensitivity of left ventricular mechanics to myofiber architecture: A finite element study.
Article in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Heart in a knot: unraveling the impact of the nested tori myofiber architecture on ventricular mechanics.Biomechanics and modeling in mechanobiology · 2025Article
- Multiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.Acta biomaterialia · 2024Article
- Comparison of interpolation methods of predominant cardiomyocyte orientation from in vivo and ex vivo cardiac diffusion tensor imaging data.NMR in biomedicine · 2022Article
- Personalization of biomechanical simulations of the left ventricle by in-vivo cardiac DTI data: Impact of fiber interpolation methods.Frontiers in physiology · 2022Article
- A Contemporary Look at Biomechanical Models of Myocardium.Annual review of biomedical engineering · 2019Review
- Automatic mapping of atrial fiber orientations for patient-specific modeling of cardiac electromechanics using image registration.International journal for numerical methods in biomedical engineering · 2019Article
- Optical coherence tomography imaging of cardiac substrates.Quantitative imaging in medicine and surgery · 2019Review
- Uncertainty in cardiac myofiber orientation and stiffnesses dominate the variability of left ventricle deformation response.International journal for numerical methods in biomedical engineering · 2019Article
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Authors and funding
3 authors.
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Abstract
The goal of this study was to investigate the sensitivity of computational models of the heart to their incorporated myofiber architecture during diastole. This architecture plays a critical role in the mechanical and electrical function of the heart and changes after myocardial tissue remodeling, which is associated with some of the most common heart diseases. In this study, a left ventricular finite element model of the porcine heart was created using magnetic resonance imaging, which represents the in vivo geometry. Various myofiber architectures were assigned to the finite element mesh, in the form of fiber and sheet angles. A structural-based material law was used to model the behavior of passive myocardium and its parameters were estimated using measured in vivo strains and cavity volume from magnetic resonance imaging. The final results showed noticeable sensitivity of the stress distribution to both the fiber and sheet angle distributions. This implies that a structural-based material law that takes into account the effect of both fiber and sheet angle distributions should be used. The results also show that although the simulation results improve using available data from histological studies of myocardial structure, the need for individualized myofiber architecture data is crucial.
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