ArticleScientific reports2016
REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Unraveling the role of MAG, PTEN, and NOTCH1 in axonal regeneration: a network analysis and molecular dynamics study of siRNA/drugs/nanocarriers interactions.Journal of translational medicine · 2025Article
- In-silico engineering of RNA nanoplatforms to promote the diabetic wound healing.BMC chemistry · 2023Article
- Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine.International journal of molecular sciences · 2022Review
- Distinct patterns of gene expression during regeneration and asexual reproduction in the annelid Pristina leidyi.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Article
- Morphological and molecular features of early regeneration in the marine annelid Ophryotrocha xiamen.Scientific reports · 2022Article
- Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.Cell discovery · 2022Article
- Regeneration Roadmap: database resources for regenerative biology.Nucleic acids research · 2022Article
- Towards comparative analyses of salamander limb regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- DNA methylation and hydroxymethylation have distinct genome-wide profiles related to axonal regeneration.Epigenetics · 2021Article
- Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.Current topics in developmental biology · 2021Review
- Data on genome annotation and analysis of earthwormData in brief · 2018Article
- CIGene: a literature-based online resource for cancer initiation genes.BMC genomics · 2018Article
- The bioelectric code: An ancient computational medium for dynamic control of growth and form.Bio Systems · 2018Review
- RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa.NPJ Regenerative medicine · 2018Article
- Network-Based Method for Identifying Co- Regeneration Genes in Bone, Dentin, Nerve and Vessel Tissues.Genes · 2017Article
- Article
- AnJournal of ophthalmic & vision researchArticle
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Regeneration is a common phenomenon across multiple animal phyla. Regeneration-related genes (REGs) are critical for fundamental cellular processes such as proliferation and differentiation. Identification of REGs and elucidating their functions may help to further develop effective treatment strategies in regenerative medicine. So far, REGs have been largely identified by small-scale experimental studies and a comprehensive characterization of the diverse biological processes regulated by REGs is lacking. Therefore, there is an ever-growing need to integrate REGs at the genomics, epigenetics, and transcriptome level to provide a reference list of REGs for regeneration and regenerative medicine research. Towards achieving this, we developed the first literature-based database called REGene (REgeneration Gene database). In the current release, REGene contains 948 human (929 protein-coding and 19 non-coding genes) and 8445 homologous genes curated from gene ontology and extensive literature examination. Additionally, the REGene database provides detailed annotations for each REG, including: gene expression, methylation sites, upstream transcription factors, and protein-protein interactions. An analysis of the collected REGs reveals strong links to a variety of cancers in terms of genetic mutation, protein domains, and cellular pathways. We have prepared a web interface to share these regeneration genes, supported by refined browsing and searching functions at http://REGene.bioinfo-minzhao.org/.
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