ArticleInternational journal of legal medicine2016
Candidate gene variants of the immune system and sudden infant death syndrome.
Article in International journal of legal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Association of IL-6 rs1800795 (- 174G > C) polymorphism with depression risk: a comprehensive meta-analysis.Scientific reports · 2026Pooled it
- Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13.International journal of legal medicine · 2024Pooled it
- Impact of PRECEDE-PROCEED model on enhancing neonatal sleep safety practices.Sleep & breathing = Schlaf & Atmung · 2025Trial
- The vicious spiral in Sudden Infant Death Syndrome.Frontiers in pediatrics · 2025Review
- Sudden Infant Death Syndrome: Beyond Risk Factors.Life (Basel, Switzerland) · 2021Review
- Genetic Factors Underlying Sudden Infant Death Syndrome.The application of clinical genetics · 2021Review
- Evidence for an association of interferon gene variants with sudden infant death syndrome.International journal of legal medicine · 2019Article
- Noncardiac genetic predisposition in sudden infant death syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study.Lancet (London, England) · 2018Article
- Comparative proteome analysis for identification of differentially abundant proteins in SIDS.International journal of legal medicine · 2017Article
- Identification of IL6 as a susceptibility gene for major depressive disorder.Scientific reports · 2016Article
- Comment on Fard et al.'s Candidate gene variants of the immune system and sudden infant death syndrome.International journal of legal medicine · 2016Article
- An Acute Respiratory Infection of a Physiologically Anemic Infant is a More Likely Cause of SIDS than Neurological Prematurity.Frontiers in neurology · 2016Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSudden infant death syndrome (SIDS) causes early infant death with an incidence between 0.5 and 2.5 cases among 1000 live births. Besides central sleep apnea and thermal dysregulation, infections have been repeatedly suggested to be implicated in SIDS etiology.
methodsTo test the risk contribution of common genetic variants related to infection, we genotyped 40 single-nucleotide polymorphisms (SNPs) from 15 candidate genes for association with SIDS in a total of 579 cases and 1124 controls from Germany and the UK in a two-stage case control design.
resultsThe discovery-stage series (267 SIDS cases and 303 controls) revealed nominally significant associations for variants in interleukin 6 (IL6) (rs1880243), interleukin 10 (IL10) (rs1800871, rs1800872), and mannose-binding lectin 2 (MBL2) (rs930506), and for several other variants in subgroups. Meta-analyses were then performed in adding genotype information from a genome-wide association study of another 312 European SIDS cases and 821 controls. Overall associations were observed for two independent variants in MBL2: rs930506 in a co-dominant model (odds ratio (OR) = 0.82, p = 0.04) and rs1838065 in a dominant model (OR = 1.27, p = 0.03).
conclusionOur study did not replicate published associations of IL10 variants with SIDS. However, the evidence for two independent MBL2 variants in the combined analysis of two large series seems consistent with the hypothesis that infection may play a role in SIDS pathogenesis.
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