Evidence map›Paper›PMID 26975710›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Association of Circulating Renin and Aldosterone With Osteocalcin and Bone Mineral Density in African Ancestry Families.

Allison L Kuipers, Candace M Kammerer, J Howard Pratt, Clareann H Bunker, Victor W Wheeler, Alan L Patrick, Joseph M Zmuda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Role of the renin-angiotensin-aldosterone system in bone metabolism.Journal of bone and mineral metabolism · 2020
    Review
  7. Mineralocorticoid Receptor Activation and Atrial Fibrosis.Hypertension (Dallas, Tex. : 1979) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Allison L KuipersFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.). kuipers@pitt.edu.
Candace M KammererFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
J Howard PrattFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
Clareann H BunkerFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
Victor W WheelerFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
Alan L PatrickFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
Joseph M ZmudaFrom the Departments of Epidemiology (A.L.K., C.H.B., J.M.Z.) and Human Genetics (C.M.K., J.M.Z.), University of Pittsburgh, PA; Department of Medicine, Indiana University School of Medicine, Indianapolis (J.H.P.); and Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago (V.W.W., A.L.P.).
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Epidemiology of Bone Loss in African MenR01AR049747 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2003 to 2014
$5.9M
Molecular Epidemiology of the Wnt Pathway in Subclinical Cardiovascular DiseaseK01HL125658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KUIPERS, ALLISON L · 2015 to 2019
$693k
Determinants of Bone Strength in Afro-Caribbean FamiliesR03AR050107 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M · 2003 to 2004
$149k
NHLBI NIH HHS K01 HL125658NHLBI NIH HHS K01-HL125658NHLBI NIH HHS T32 HL083825NHLBI NIH HHS T32-HL083825NIAMS NIH HHS R01 AR049747NIAMS NIH HHS R01-AR049747NIAMS NIH HHS R03 AR050107NIAMS NIH HHS R03-AR050107
6 · The paper itself

Abstract

Hypertension is associated with accelerated bone loss, and the renin-angiotensin-aldosterone system is a key regulator of blood pressure. Although components of this system are expressed in human bone cells, studies in humans are sparse. Thus, we studied the association of circulating renin and aldosterone with osteocalcin and bone mineral density. We recruited 373 African ancestry family members without regard to health status from 6 probands (mean family size: 62 and relative pairs: 1687). Participants underwent a clinical examination, dual-energy x-ray absorptiometry, and quantitative computed tomographic scans. Renin activity, aldosterone concentration, and osteocalcin were measured in fasting blood samples. Aldosterone/renin ratio was calculated as aldosterone concentration/renin activity. All models were analyzed using pedigree-based variance components methods. Full models included adjustment for age, sex, body composition, comorbidities, lifestyle factors, blood pressure, and antihypertensive medication. Higher renin activity was significantly associated with lower total osteocalcin and with higher trabecular bone mineral density (both P<0.01). There were also significant genetic correlations between renin activity and whole-body bone mineral density. There were no associations with aldosterone concentration in any model and results for aldosterone/renin ratio were similar to those for renin activity. This is the first study to report a significant association between renin activity and a marker of bone turnover and bone mineral density in generally healthy individuals. Also, there is evidence for significant genetic pleiotropy and, thus, there may be a shared biological mechanism underlying both the renin-angiotensin-aldosterone system and bone metabolism that is independent of hypertension.

Indexed as

AdultAgedAge FactorsAldosteroneAnthropometryBiomarkersBlack PeopleBody Mass IndexBone DensityCohort StudiesFemaleHumansHypertensionMaleMiddle AgedOsteocalcinAldosteroneBiomarkersOsteocalcinReninaldosteronebone densityhypertensionosteocalcinrenin

Identifiers

PMID26975710
PMCPMC4833607
OpenAlexW2297763478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.